4-[(5-chloropyridin-2-yl)methoxy]-1-(4-{2-[(3S)-3-fluoropyrrolidin-1-yl]ethyl}phenyl)pyridin-2(1H)-one | 927892-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[(5-chloropyridin-2-yl)methoxy]-1-(4-{2-[(3S)-3-fluoropyrrolidin-1-yl]ethyl}phenyl)pyridin-2(1H)-one
• 英文别名: 4-[(5-chloropyridin-2-yl)methoxy]-1-[4-[2-[(3S)-3-fluoropyrrolidin-1-yl]ethyl]phenyl]pyridin-2-one
• CAS: 927892-61-3
• 化学式: C₂₃H₂₃ClFN₃O₂
• 分子量: 427.906
• InChiKey: JNCCLLLZUJGJIX-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  45.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Phenylpyridone Derivative
  申请人：Naya Akira

  公开号：US20090137587A1

  公开（公告）日：2009-05-28

  A compound represented by the formula (I) is contained as an active ingredient: wherein R 1 and R 2 independently represent a hydrogen atom, a lower alkyl group or the like, or R 1 together with a nitrogen atom to which L, Z 2 and R 1 are attached may form an aliphatic nitrogenated heterocyclic group and R 1 and R 2 together with a nitrogen atom to which they are attached may form an aliphatic nitrogenated heterocyclic group; X represents a methine group or a nitrogen atom; Y represents —CH 2 —O—, —CH═CH— or the like; Z 1 represents a single bond, a C 1-4 alkylene group or the like; Z 2 represents a single bond or a C 1-4 alkylene group; L represents a methylene group, a C 3-8 cycloalkylene group or the like; and Ar represents an aromatic carbocyclic group or the like. The compound is useful as a pharmaceutical for a central nerves system disease, a cardiovascular disease or a metabolic disease.

  化合物的化学式为（I），其中包含作为活性成分的化合物：其中R1和R2独立地表示氢原子，低碳基团或类似物，或者R1与L，Z2和R1附着的氮原子一起可以形成脂肪族氮杂环基团，R1和R2与它们附着的氮原子一起可以形成脂肪族氮杂环基团；X表示亚甲基基团或氮原子；Y表示-CH2-O-，-CH═CH-或类似物；Z1表示单键，C1-4烷基撇或类似物；Z2表示单键或C1-4烷基撇；L表示亚甲基基团，C3-8环烷基撇或类似物；Ar表示芳香族碳环基团或类似物。该化合物可用作中枢神经系统疾病、心血管疾病或代谢性疾病的药物。
• PHENYLPYRIDONE DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1921065B1

  公开（公告）日：2010-10-20
• US7875633B2
  申请人：——

  公开号：US7875633B2

  公开（公告）日：2011-01-25