(3-bromo-4-chlorophenoxy)-t-butyldimethylsilane | 151692-21-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-bromo-4-chlorophenoxy)-t-butyldimethylsilane
• 英文别名: (3-bromo-4-chloro-phenoxy)-tert-butyl-dimethyl-silane；(3-bromo-4-chlorophenoxy)-tert-butyl-dimethylsilane
• CAS: 151692-21-6
• 化学式: C₁₂H₁₈BrClOSi
• 分子量: 321.717
• InChiKey: NVRHVWNPCXFTEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.49
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3-bromo-4-chlorophenoxy)-t-butyldimethylsilane 在 bis-triphenylphosphine-palladium(II) chloride 、 三丁基氯化锡 、 叔丁基锂 、 potassium amide 作用下， 以 氨 为溶剂， 反应 3.0h， 生成 3-甲基-6-羟基咔唑
  参考文献：
  名称：

  A Regiospecific Synthesis of Carbazoles via Consecutive Palladium-catalyzed Cross-coupling and Aryne-mediated Cyclization

  摘要：

  A regiospecific synthesis of carbazoles has been developed using palladium-catalyzed cross-coupling of N-(tert-butoxycarbonyl)-2-tributylstannylanilines with 2- or 3-bromochlorobenzene followed by aryne-mediated cyclization as the key reactions. The carbazole alkaloids, glycozolinine and glycozolidine, were synthesized using this procedure.

  DOI：

  10.3987/com-93-6368
• 作为产物：
  描述：

  tert-butyl(4-chlorophenoxy)dimethylsilane 在 1,1,2,2-四氟-1,2-二溴乙烷 、 仲丁基锂 作用下， 生成 (3-bromo-4-chlorophenoxy)-t-butyldimethylsilane
  参考文献：
  名称：

  A Regiospecific Synthesis of Carbazoles via Consecutive Palladium-catalyzed Cross-coupling and Aryne-mediated Cyclization

  摘要：

  A regiospecific synthesis of carbazoles has been developed using palladium-catalyzed cross-coupling of N-(tert-butoxycarbonyl)-2-tributylstannylanilines with 2- or 3-bromochlorobenzene followed by aryne-mediated cyclization as the key reactions. The carbazole alkaloids, glycozolinine and glycozolidine, were synthesized using this procedure.

  DOI：

  10.3987/com-93-6368

文献信息

• [EN] SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS<br/>[FR] ANILINES SUBSTITUÉES EN TANT QU'ANTAGONISTES DE CCR(4)
  申请人：CHEMOCENTRYX INC

  公开号：WO2013082490A1

  公开（公告）日：2013-06-06

  Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.

  提供了结合到CCR(4)并且用于治疗过敏疾病、自身免疫疾病、移植排斥和癌症等疾病的苯胺化合物。
• SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS
  申请人：ChemoCentryx, Inc.

  公开号：US20130172315A1

  公开（公告）日：2013-07-04

  Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.

  提供了结合CCR（4）并用于治疗过敏性疾病、自身免疫性疾病、移植排斥和癌症等疾病的苯胺化合物。
• Substituted anilines as CCR(4) antagonists
  申请人：ChemoCentryx, Inc.

  公开号：US08835419B2

  公开（公告）日：2014-09-16

  Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.

  提供了可与CCR（4）结合并用于治疗过敏性疾病、自身免疫性疾病、移植排斥和癌症等疾病的苯胺化合物。
• A Regiospecific Synthesis of Carbazoles via Consecutive Palladium-catalyzed Cross-coupling and Aryne-mediated Cyclization
  作者：Masatomo Iwao、Hirokazu Takehara、Sunao Furukawa、Mitsuaki Watanabe

  DOI：10.3987/com-93-6368

  日期：——

  A regiospecific synthesis of carbazoles has been developed using palladium-catalyzed cross-coupling of N-(tert-butoxycarbonyl)-2-tributylstannylanilines with 2- or 3-bromochlorobenzene followed by aryne-mediated cyclization as the key reactions. The carbazole alkaloids, glycozolinine and glycozolidine, were synthesized using this procedure.