AC-Gly-OH | 85622-08-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: AC-Gly-OH
• 英文别名: N-[(2z)-3-hydroxy-1-methyl-2-butenylidene]glycine；2-[[(Z)-4-oxopent-2-en-2-yl]amino]acetic acid
• CAS: 85622-08-8
• 化学式: C₇H₁₁NO₃
• 分子量: 157.169
• InChiKey: AAJSCKSXHMBOTB-HYXAFXHYSA-N

物化性质

• 沸点：
  342.5±27.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  聚甘氨酸 、 乙酰丙酮 以 水 、 二甲基亚砜 、 乙腈 为溶剂， 生成 AC-Gly-OH
  参考文献：
  名称：

  Rapid analysis of solvent effects on enamine formation by fluorescence: how might enzymes facilitate enamine chemistry with primary amines?

  摘要：

  In order to determine factors that facilitate the use of primary amines in biological chemistry, solvent effects on enamine formation with glycine were studied. Solvent effects were rapidly analyzed by monitoring the increase in fluorescence resulting from the reaction between a fluorogenic maleimide and in situ-generated enamine of acetone. These studies suggest that in addition to a simple hydrophobic microenvironment, a microenvironment that also affords for hydrogen bond formation facilitates enamine-based reactions involving primary amines. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.10.157