N-Hydroxymethyl norzolpidem | 172481-19-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-Hydroxymethyl norzolpidem
• 英文别名: N-(hydroxymethyl)-N-methyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
• CAS: 172481-19-5
• 化学式: C₁₉H₂₁N₃O₂
• 分子量: 323.4
• InChiKey: KUSAOXWXNBBGIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SYNTHESIS OF HETEROARYL ACETAMIDES<br/>[FR] SYNTHESE D'ACETAMIDES D'HETEROARYLE
  申请人：MALLINCKRODT INC

  公开号：WO2004058758A1

  公开（公告）日：2004-07-15

  An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provied. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide in the presence of a strong acid, a halide and a catalyst. In one embodiment, the heteroaryl acetamide is zolpidem and the heteroaryl α-hydroxyacetamide is α-hydroxyzolpidem.

  提供一种改进的方法，用于从杂环α-羟基乙酰胺制备杂环醋酰胺。该方法包括在强酸、卤化物和催化剂存在下直接氢化杂环α-羟基乙酰胺。在一个实施例中，杂环醋酰胺是唑吡坦，杂环α-羟基乙酰胺是α-羟基唑吡坦。
• Synthesis Of Heteroaryl Acetamides From Reaction Mixtures Having Reduced Water Content
  申请人：Jarvi Esa

  公开号：US20070213537A1

  公开（公告）日：2007-09-13

  An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provided. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide in the presence of a strong acid, a halide and a catalyst wherein the molar ratio of the starting heteroaryl α-hydroxyacetamide to water at the initiation of hydrogenolysis is at least about 2:1. In one embodiment, the heteroaryl acetamide is zolpidem and the heteroaryl α-hydroxyacetamide is α-hydroxyzolpidem.

  提供了一种改进的方法，用于从杂环α-羟基乙酰胺制备杂环醋酰胺。该方法包括在强酸、卤化物和催化剂的存在下直接加氢杂环α-羟基乙酰胺，其中在氢解反应开始时，起始杂环α-羟基乙酰胺与水的摩尔比至少为2:1。在一个实施例中，杂环醋酰胺是唑吡坦，而杂环α-羟基乙酰胺是α-羟基唑吡坦。
• SYNTHESIS OF HETEROARYL ACETAMIDES
  申请人：MALLINCKRODT INC.

  公开号：EP1575952B1

  公开（公告）日：2009-02-18
• SYNTHESIS OF HETEROARYL ACETAMIDES FROM REACTION MIXTURES HAVING REDUCED WATER CONTENT
  申请人：MALLINCKRODT, INC.

  公开号：EP1809627B1

  公开（公告）日：2009-12-09
• Synthesis of heteroaryl acetamides
  申请人：Jarvi T Esa

  公开号：US20060025588A1

  公开（公告）日：2006-02-02

  An improved process for the preparation of a heteroaryl acetamide from a heteroaryl α-hydroxyacetamide is provied. The process comprises directly hydrogenating the heteroaryl α-hydroxyacetamide in the presence of a strong acid, a halide and a catalyst. In one embodiment, the heteroaryl acetamide is zolpidem and the heteroaryl α-hydroxyacetamide is α-hydroxyzolpidem.