N-(2-Hydroxy-cyclohexyl)-glycin | 18217-06-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-Hydroxy-cyclohexyl)-glycin
• 英文别名: 2-[(2-Hydroxycyclohexyl)amino]acetic acid
• CAS: 18217-06-6
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: JCQXAVGQGFWHAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1R,2R-trans-2-{[2-(4-chloro-3-methylphenoxy)ethyl]amino}cyclohexan-1-ol 在 glucose-6-phosphate dehydrogenase 、 烟酰胺腺嘌呤双核苷酸磷酸盐 、 D-glucose 6-phosphate 作用下， 以 aq. phosphate buffer 为溶剂， 反应 1.25h， 生成 2-Chloro-5-[2-[(2-hydroxycyclohexyl)amino]ethoxy]benzoic acid 、 N-(2-Hydroxy-cyclohexyl)-glycin
  参考文献：
  名称：

  反式-2-氨基环己-1-醇的4-氯-3-甲基苯氧基乙胺衍生物的合成，抗惊厥活性和代谢

  摘要：

  在这项研究中，我们报告了反式-2氨基环己-1-醇的三种新的手性N-氨基烷基衍生物的合成，光谱表征，抗癫痫活性和生物转化：1（R对映体），2（S对映体）和3（消旋剂）。使用MES和scMet研究了标题化合物的抗癫痫活性。此外，在该研究中，生物转化1，2和3中的微生物模型（银汉），肝微粒体分析以及在计算机芯片上研究（MetaSite）进行评价。

  DOI：

  10.1002/chir.22406

文献信息

• NOVEL SUPERCOOLING METHODS FOR PRESERVATION OF BIOLOGICAL SAMPLES
  申请人：X-Therma, Inc.

  公开号：US20200170241A1

  公开（公告）日：2020-06-04

  The present invention provides methods for cryopreserving a population of cells with improved cell viability. In some aspects, the method comprises contacting a population of cells with a peptoid polymer comprising one or more polar peptoid monomers, e.g., formulated in a cryoprotectant solution, and cooling the population of cells at a temperature of from 0° C. to about −20° C. for a time period of at least about 3 hours to produce a population of supercooled cells. The supercooling methods of the present invention provide excellent post-thaw cell survival and recovery. In certain embodiments, the population of cells is present in a tissue or an organ that is cryopreserved by performing the supercooling methods of the present invention.
• NOVEL PEPTOID POLYMERS AND METHODS OF USE
  申请人：X-Therma, Inc.

  公开号：US20200239632A1

  公开（公告）日：2020-07-30

  The present invention provides peptoid polymers and salts thereof that comprise hydrophobic and polar peptoid monomers and are capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids and salts thereof comprising the peptoid polymers provided herein. The peptoid polymers, peptoid-peptide hybrids, and salts thereof provided herein are useful for making cryoprotectant solutions. The peptoid polymers, peptoid-peptide hybrids, salts thereof, and cryoprotectant solutions provided herein are useful for making antifreeze solutions, frozen food products, and cosmetic care products. Also provided herein are methods for preserving a tissue, an organ, a cell, or a biological macromolecule using the compositions described herein.