1,4-diacetoxy-2,3-dimethoxy-5-methylbenzene | 22028-20-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 1,4-diacetoxy-2,3-dimethoxy-5-methylbenzene
• 英文别名: ubiquinol-0 diacetate；2,3-Dimethoxy-5-methylhydrochinon-diacetat；2.5-Diacetoxy-3.4-dimethoxy-toluol；1,4-diacetoxy-5,6-dimethoxy-2-methylbenzene；(4-acetyloxy-2,3-dimethoxy-5-methylphenyl) acetate
• CAS: 22028-20-2
• 化学式: C₁₃H₁₆O₆
• 分子量: 268.266
• InChiKey: GLRSUPHADHFHDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,4-diacetoxy-2,3-dimethoxy-5-methylbenzene 在 盐酸 、 potassium carbonate 作用下， 以 甲醇 为溶剂， 以90%的产率得到4-acetoxy-2,3-dimethoxy-5-methylphenol
  参考文献：
  名称：

  Quinone compound, its production and use as antioxidant

  摘要：

  式（I）的化合物：##STR1##其中，R.sup.1、R.sup.2和R.sup.3独立地表示H、可选酰化的羟基、可选取代的氨基、可选取代的烷氧基或可选取代的碳氢基，或R.sup.2和R.sup.3可形成可选取代的碳氢环；R.sup.4表示烷基；R.sup.5表示可选取代的羟基；R.sup.6和R.sup.7独立地表示可选取代的碳氢基或R.sup.6和R.sup.7形成可选取代的环；m表示1或2；n表示1至5的整数；或羟基苯醌衍生物或其盐具有抑制脂质过氧化物形成的作用，可用作治疗或预防中枢神经系统疾病、循环系统疾病等的药物。

  公开号：

  US06011046A1
• 作为产物：
  描述：

  4-羟基-3-甲氧基-2-硝基苯甲醛 在 五氯化磷 、 硝酸 、 sodium acetate 、 potassium carbonate 、 二氧化氮 、 锌 作用下， 以 溶剂黄146 、 丙酮 、 苯 为溶剂， 生成 1,4-diacetoxy-2,3-dimethoxy-5-methylbenzene
  参考文献：
  名称：

  Koshi,K.; Shimizu,M., Chemical and pharmaceutical bulletin, 1968, vol. 16, p. 2343 - 2350

  摘要：

  DOI：

文献信息

• Quinone compound, its production and use as antioxidant
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US06011046A1

  公开（公告）日：2000-01-04

  A compound of the formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent H, an optionally acylated hydroxyl group, an optionally substituted amino group, an optionally substituted alkoxy group or an optionally substituted hydrocarbon group, or R.sup.2 and R.sup.3 may form an optionally substituted hydrocarbon ring; R.sup.4 represents an alkyl group; R.sup.5 represents an optionally substituted hydroxyl group; R.sup.6 and R.sup.7 independently represent an optionally substituted hydrocarbon group or R.sup.6 and R.sup.7 form an optionally substituted ring; m represents 1 or 2; and n represents an integer of 1 to 5; or a hydroquinone derivative or a salt thereof has lipoperoxide formation inhibitory effect and is useful as a medicine for treating or preventing central nervous system disorders, diseases in the circulatory system, etc.

  式（I）的化合物：##STR1##其中，R.sup.1、R.sup.2和R.sup.3独立地表示H、可选酰化的羟基、可选取代的氨基、可选取代的烷氧基或可选取代的碳氢基，或R.sup.2和R.sup.3可形成可选取代的碳氢环；R.sup.4表示烷基；R.sup.5表示可选取代的羟基；R.sup.6和R.sup.7独立地表示可选取代的碳氢基或R.sup.6和R.sup.7形成可选取代的环；m表示1或2；n表示1至5的整数；或羟基苯醌衍生物或其盐具有抑制脂质过氧化物形成的作用，可用作治疗或预防中枢神经系统疾病、循环系统疾病等的药物。
• Process for the Preparation of Ubihydroquinones and Ubiquinones
  申请人：Aquino Fabrice

  公开号：US20080275275A1

  公开（公告）日：2008-11-06

  A process for the preparation of ubihydroquinones and ubiquinones by condensation of a prenol or isoprenol with a hydroquinone or derivative thereof in the presence of 0.005-1.0 mol % of a catalyst which is a Broensted-acid, a Lewis-acid from the group consisting of a derivative of Bi or In or an element of group 3 of the periodic table of the elements, a heteropolyacid, an NH- or a CH-acidic compound, and optionally oxidizing the ubihydroquinone obtained.

  一种制备辅酶喹酮和辅醌的方法，通过在存在0.005-1.0摩尔％催化剂的条件下，将藤黄烯醇或异藤黄烯醇与羟基苯醌或其衍生物缩合，所述催化剂为Broensted酸、来自Bi或In衍生物或元素3的Lewis酸、杂多酸、NH-或CH-酸性化合物，可选地氧化获得的辅酶喹酮。
• Active oxygen chemistry within the liposomal bilayer
  作者：Michal Afri、Benjamin Ehrenberg、Yeshayahu Talmon、Judith Schmidt、Yael Cohen、Aryeh A. Frimer

  DOI：10.1016/j.chemphyslip.2004.04.007

  日期：2004.8

  We have previously shown that the location and orientation of compounds intercalated within the lipid bilayer can be qualitatively determined using an NMR chemical shift-polarity correlation. We describe herein the results of our application of this method to analogs of Vitamin E, ubiquinol and ubiquinone. The results indicate that tocopherol-and presumably the corresponding tocopheroxyl radical-reside adjacent to the interface, and can, therefore, abstract a hydrogen atom from ascorbic acid. On the other hand, the decaprenyl substituted ubiquinol and ubiquinone lie substantially deeper within the lipid membrane. Yet, contrary to the prevailing literature, their location is far from being the same. Ubiquinone-10 is situated above the long-chain fatty acid "slab". Ubiquinol-10 dwells well within the lipid slab, presumably out of "striking range" of Vitamin C. Nevertheless, ubiquinol can act as an antioxidant by reducing C- or O-centered lipid radicals or by recycling the lipid-resident tocopheroxyl radical. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
• QUINONE COMPOUND, ITS PRODUCTION AND USE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0846109A1

  公开（公告）日：1998-06-10
• PROCESS FOR THE PREPARATION OF UBIHYDROQUINONES AND UBIQUINONES
  申请人：DSM IP Assets B.V.

  公开号：EP1915333A1

  公开（公告）日：2008-04-30