ethyl N-[(Z)-1-(hydroxyamino)ethylideneamino]carbamate | 107448-74-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl N-[(Z)-1-(hydroxyamino)ethylideneamino]carbamate
• CAS: 107448-74-8
• 化学式: C₅H₁₁N₃O₃
• 分子量: 161.161
• InChiKey: CDPOKKXLMDBVHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  83
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl N-[(Z)-1-(hydroxyamino)ethylideneamino]carbamate 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以79%的产率得到4-hydroxy-3-methyl-1H-1,2,4-triazol-5-one
  参考文献：
  名称：

  Synthesis of 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones

  摘要：

  A series of hydroxamic acid ethoxycarbonylhydrazides was obtained by reactions of ester ethoxycarbonylhydrazones with hydroxylamine. The corresponding 3-substituted 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones were synthesized by cyclization of these hydroxamic acid derivatives in basic medium.

  DOI：

  10.1007/bf00810474
• 作为产物：
  描述：

  (1-乙氧基乙基亚基)肼基甲酸乙酯 在 羟胺 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以65%的产率得到ethyl N-[(Z)-1-(hydroxyamino)ethylideneamino]carbamate
  参考文献：
  名称：

  Synthesis of 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones

  摘要：

  A series of hydroxamic acid ethoxycarbonylhydrazides was obtained by reactions of ester ethoxycarbonylhydrazones with hydroxylamine. The corresponding 3-substituted 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones were synthesized by cyclization of these hydroxamic acid derivatives in basic medium.

  DOI：

  10.1007/bf00810474

文献信息

• Synthesis of 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones
  作者：A. Aykut İkizler、Kemal Sancak

  DOI：10.1007/bf00810474

  日期：1992.3

  A series of hydroxamic acid ethoxycarbonylhydrazides was obtained by reactions of ester ethoxycarbonylhydrazones with hydroxylamine. The corresponding 3-substituted 4-hydroxy-4,5-dihydro-1,2,4-triazol-5-ones were synthesized by cyclization of these hydroxamic acid derivatives in basic medium.