5-isopropyl-3-(4-methoxyphenyl)-1H-pyrazole | 1440955-54-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-isopropyl-3-(4-methoxyphenyl)-1H-pyrazole
• 英文别名: 3-(4-methoxyphenyl)-5-propan-2-yl-1H-pyrazole
• CAS: 1440955-54-3
• 化学式: C₁₃H₁₆N₂O
• 分子量: 216.283
• InChiKey: NDMQBJQYDWQOBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL COMPOUNDS
  申请人：GRAUERT Matthias

  公开号：US20130137688A1

  公开（公告）日：2013-05-30

  This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R 1 , R 2 , R 3 have meanings given in the description.

  这项发明涉及到式I的化合物，它们作为mGlu5受体活性的正向变构调节剂的用途，含有这些化合物的药物组合物，以及将其用作治疗和/或预防与谷氨酸功能障碍相关的神经和精神障碍，如精神分裂症或认知功能下降，如痴呆症或认知障碍的药剂的方法。A、B、Ar、R1、R2、R3在描述中有给定的含义。
• PYRIMIDINONE-CONTAINING COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
  申请人：YUNNAN UNIVERSITY

  公开号：US20200399248A1

  公开（公告）日：2020-12-24

  Disclosed is a pyrimidinone-containing compound represented by formula I, a preparation method thereof, a pharmaceutical composition, and an application thereof. The pyrimidinone-containing compound of the present disclosure can be used as HIV-1 inhibitor and can be also used in the treatment of human immunodeficiency virus infection.

  本公开揭示了一种含有嘧啶酮基团的化合物，其化学式如下（I），以及其制备方法、药物组合物和应用。本公开的含有嘧啶酮基团的化合物可用作HIV-1抑制剂，也可用于治疗人类免疫缺陷病毒感染。
• 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS
  申请人：Shipps, JR. Gerald W.

  公开号：US20100055090A1

  公开（公告）日：2010-03-04

  The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
• US8227605B2
  申请人：——

  公开号：US8227605B2

  公开（公告）日：2012-07-24
• US8822464B2
  申请人：——

  公开号：US8822464B2

  公开（公告）日：2014-09-02