N-[(2R)-2-(2-chlorophenyl)-1-hydroxypropan-2-yl]-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide | 1245620-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[(2R)-2-(2-chlorophenyl)-1-hydroxypropan-2-yl]-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide
• 英文别名: N-[(2R)-2-(2-chlorophenyl)-1-hydroxypropan-2-yl]-2-[3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-1,2,4-triazol-1-yl]acetamide
• CAS: 1245620-77-2
• 化学式: C₂₂H₂₁Cl₂F₃N₄O₄
• 分子量: 533.334
• InChiKey: CIQFEIAZSXQYPE-UWJYYQICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• SUBSTITUTED 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONES AND USE THEREOF
  申请人：Brüggemeier Ulf

  公开号：US20100261771A1

  公开（公告）日：2010-10-14

  The present application relates to new, substituted 2-acetamido-5-aryl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新的、取代的2-乙酰胺基-5-芳基-1,2,4-三唑酮，以及制备它们的方法，它们单独或组合用于治疗和/或预防疾病，以及它们用于生产用于治疗和/或预防疾病的药物，更具体地用于治疗和/或预防心血管疾病。
• Electrostatic powder coating method and powder coating material
  申请人：FUJI XEROX CO., LTD.

  公开号：US10195641B2

  公开（公告）日：2019-02-05

  An electrostatic powder coating method includes spraying a charged powder coating material including powder particles that contain a thermosetting resin and a thermosetting agent, and an external additive that includes oxide particles containing at least one of titania and alumina to electrostatically attach the powder coating material to an object to be coated, and heating the powder coating material that is electrostatically attached to the object to be coated to thereby form a coating film, wherein a content Ac of the oxide particles in the powder coating material that is electrostatically attached to the object to be coated and a content Ao of the oxide particles in the powder coating material before being sprayed satisfy a relationship of Expression: Ao×0.80≤Ac≤Ao×1.20.

  一种静电粉末喷涂方法包括喷涂带电粉末涂料，该粉末涂料包括含有热固性树脂和热固性剂的粉末颗粒，以及包括含有二氧化钛和氧化铝中至少一种的氧化物颗粒的外部添加剂，以将粉末涂料静电附着到待喷涂物体上、加热静电附着到待涂覆物体上的粉末涂料，从而形成涂膜，其中静电附着到待涂覆物体上的粉末涂料中氧化物颗粒的含量 Ac 与喷涂前粉末涂料中氧化物颗粒的含量 Ao 满足 Expression：Ao×0.80≤Ac≤Ao×1.20。
• Substituierte 2-acetamido-5-aryl-1,2,4-triazolone und deren Verwendung
  申请人：Bayer Intellectual Property GmbH

  公开号：EP2408751B1

  公开（公告）日：2017-08-23
• Cellulose ester film, polarizing plate and liquid crystal display
  申请人：Oka Shigeki

  公开号：US20060280882A1

  公开（公告）日：2006-12-14

  An object of the present invention is to provide a polarizing plate protective film exhibiting a reduced variation value retardation, which is highly stable against polarizing plate degradation, polarizing plate dimension, and polarizing plate curl. Disclosed is a cellulose ester film possessing cellulose ester, polymer X having a weight average molecular weight of 2000-30000 prepared by copolymerizing ethylenic unsaturated monomer Xa containing no aromatic ring and hydrophilic group within a molecule and ethylenic unsaturated monomer Xb containing no aromatic ring but a hydrophilic group within a molecule, and polymer Y having a weight average molecular weight of 500-3000 prepared by polymerizing ethylenic unsaturated monomer Ya containing no aromatic ring.
• THERMOSETTING POWDER COATING MATERIAL, AND COATED ARTICLE
  申请人：FUJI XEROX CO., LTD.

  公开号：US20150353762A1

  公开（公告）日：2015-12-10

  A thermosetting powder coating material includes powder particles that contain a core containing a thermosetting resin and a thermosetting agent, and a resin coating portion for coating a surface of the core, and of which a volume particle size distribution index GSDv is equal to or smaller than 1.50 and an average circularity is equal to or greater than 0.96.