| 1454332-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• CAS: 1454332-62-7
• 化学式: C₂₇H₂₇ClN₂O₅
• 分子量: 494.975
• InChiKey: UPWQPOBKNHAHQR-UHFFFAOYSA-N

物化性质

• 熔点：
  140-144 °C
• 沸点：
  653.2±55.0 °C(predicted)
• 密度：
  1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  5-氯靛红 、 乙酰乙酸乙酯 、 乙烷,三氯氟- 在 montmorillonite KSF 作用下， 反应 0.12h， 以94%的产率得到
  参考文献：
  名称：

  Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections

  摘要：

  An environmentally benign solvent free synthesis of various spiro-1,4-dihydropyridines (1,4-DHPs) incorporating 2-oxindole/piperidines is performed in 5-8 min with reasonable purity in 80-90% yield under microwave irradiation using montmorillonite KSF as an inorganic solid support. The reaction is found to be general with respect to various cyclic carbonyl compounds, e.g. cyclohexanone, substituted indole-2,3-dione, and piperidinone derivatives. In our study, these compounds were also found effective against dermatophytes and other fungal organisms. Our results suggest that novel spiro derivatives can be used for the treatment of dermatophytosis or ringworm infections.

  DOI：

  10.1134/s106816201303014x