methyl 2,3,4,6-tetra-O-acetyl-α-L-mannopyranoside | 141042-95-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2,3,4,6-tetra-O-acetyl-α-L-mannopyranoside
• 英文别名: (2S,3S,4R,5R,6R)-2-(acetoxymethyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate；[(2S,3S,4R,5R,6R)-3,4,5-triacetyloxy-6-methoxyoxan-2-yl]methyl acetate
• CAS: 141042-95-7
• 化学式: C₁₅H₂₂O₁₀
• 分子量: 362.334
• InChiKey: UYWUMFGDPBMNCA-VQJWOFKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.28
• 重原子数：
  25.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  123.66
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为产物：
  描述：

  (2S,3R,4R,5R,6R)-2-(hydroxymethyl)-6-methoxytetrahydropyran-3,4,5-triol 、 乙酸酐 在 吡啶 作用下， 以53.3%的产率得到methyl 2,3,4,6-tetra-O-acetyl-α-L-mannopyranoside
  参考文献：
  名称：

  WO2019236775A5

  摘要：

  公开号：

  WO2019236775A5

文献信息

• Easy Access to<scp>L</scp>-Mannosides and<scp>L</scp>-Galactosides by Using CH Activation of the Corresponding 6-Deoxysugars
  作者：Tobias Gylling Frihed、Mads Heuckendorff、Christian Marcus Pedersen、Mikael Bols

  DOI：10.1002/anie.201206880

  日期：2012.12.3

  Rare sugars by CH activation: The title compounds have been prepared from the corresponding 6‐deoxysugars by an intramolecular CH activation in high yields. Diethyl silane is attached to the 4‐OH group followed by formation of a SiC bond; both transformations are catalyzed by iridium in a one‐pot fashion. The subsequent Fleming–Tamao oxidation provided the L‐sugars.

  稀有糖由CH活化：已经从由分子内C中的相应的6-脱氧糖制备标题化合物 ħ激活以高收率。将二乙基硅烷连接至4-OH基团，然后形成SiC键；铱以一种一锅法的方式催化了这两种转化。随后的弗莱明-塔莫氧化产生了L型糖。
• Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US10953027B2

  公开（公告）日：2021-03-23

  Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

  本文公开了活性剂、含有活性剂的组合物、含有活性剂的单位剂型以及活性剂的使用方法，例如用于治疗代谢紊乱或非酒精性脂肪肝或调节代谢标志物或非酒精性脂肪肝标志物。
• ACTIVE AGENTS AND METHODS OF THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS AND NONALCOHOLIC FATTY LIVER DISEASE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20200197428A1

  公开（公告）日：2020-06-25

  Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.