3-Pentyl-4,5-diamino-1,2,4-triazol | 14624-58-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Pentyl-4,5-diamino-1,2,4-triazol
• 英文别名: 5-Pentyl-1,2,4-triazole-3,4-diamine
• CAS: 14624-58-9
• 化学式: C₇H₁₅N₅
• 分子量: 169.23
• InChiKey: RFPNWMGFDUWBDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• EP1576093A4
  申请人：——

  公开号：EP1576093A4

  公开（公告）日：2009-07-08
• 3-DEOXYGLUCOSONE AND SKIN
  申请人：Dynamis Therapeutics, Inc.

  公开号：EP1576093A2

  公开（公告）日：2005-09-21
• FRUCTOSEAMINE 3 KINASE AND THE FORMATION OF COLLAGEN AND ELASTIN
  申请人：Dynamis Therapeutics, Inc.

  公开号：EP1753861A2

  公开（公告）日：2007-02-21
• [EN] 3-DEOXYGLUCOSONE AND SKIN<br/>[FR] 3-DESOXYGLUCOSONE ET LA PEAU
  申请人：DYNAMIS THERAPEUTICS INC

  公开号：WO2003089601A2

  公开（公告）日：2003-10-30

  The invention relates to the discovery that 3-deoxyglucosone (3DG) and other alpha-dicarbonyl sugars associated diseases and disorders are present and produced in the skin. Further, the invention relates to the discovery that amadorase, an enzyme that mediates 3DG synthesis, is also present in the skin. Thus, the invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha­dicarbonyl sugars in skin thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.
• [EN] FRUCTOSEAMINE 3 KINASE AND THE FORMATION OF COLLAGEN AND ELASTIN<br/>[FR] FRUCTOSAMINE-3-KINASE ET LA FORMATION DE COLLAGENE ET D'ELASTINE
  申请人：DYNAMIS THERAPEUTICS INC

  公开号：WO2005079463A2

  公开（公告）日：2005-09-01

  The invention relates to the discovery that levels of collagen and elastin can be modulated by changing the flux through the Amadori Pathway and that copper containing compounds and complexes inhibit the enzyme fructoseamine-3-­kinase.