4-(4-fluorophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole | 1155056-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-fluorophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole
• 英文别名: 5-(4-fluorophenyl)-2-pyrrolidin-2-yl-1H-imidazole
• CAS: 1155056-60-2
• 化学式: C₁₃H₁₄FN₃
• mdl: MFCD12105656
• 分子量: 231.27
• InChiKey: ALHPQZHCDUZSKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] NOVEL BETULINIC ACID PROLINE DERIVATIVES AS HIV INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS PROLINE DE L'ACIDE BÉTULINIQUE UTILISÉS COMME INHIBITEURS DU VIH
  申请人：HETERO RESEARCH FOUNDATION

  公开号：WO2014105926A1

  公开（公告）日：2014-07-03

  The invention relates to novel betulinic acid derivatives and related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases. These compounds are esterified in position 3 and are substituted in position 17 of the betulinic acid structure, via a linking group W, by a saturated 5-7 membered nitrogen-heterocycle.

  这项发明涉及新型苦药酸衍生物和相关化合物，以及用于治疗病毒性疾病特别是HIV介导疾病的药物组合物。这些化合物在苦药酸结构的3位酯化，并且在17位通过连接基团W被取代，取代基是饱和的5-7元氮杂环。
• [EN] NOVEL C28-ANALOGUES WITH C3-MODIFICATIONS OF TRITERPENE DERIVATIVES AS HIV INHIBITORS<br/>[FR] NOUVEAUX ANALOGUES DE C28 À MODIFICATIONS EN C3 DE DÉRIVÉS TRITERPÉNIQUES À UTILISER EN TANT QU'INHIBITEURS DU VIH
  申请人：HETERO RESEARCH FOUNDATION

  公开号：WO2017025901A1

  公开（公告）日：2017-02-16

  The present invention relates to compounds of novel C28-analogues with C3- modifications of triterpene derivatives of formula (I); or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, and Z are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) useful for the treatment of viral diseases and particularly HIV mediated diseases.

  本发明涉及具有新型C28类似物和三萜衍生物的C3修饰的化合物的公式(I)；或药学上可接受的盐、药学上可接受的溶剂化合物、药学上可接受的水合物、互变异构体、立体异构体、前药、组合物或其组合物，其中R1、R2、R3、R4、R5、R6、R7、R8、X和Z如本文所定义。本发明还涉及包含公式(I)化合物的药物组合物，用于治疗病毒性疾病，特别是HIV介导的疾病。
• NOVEL BETULINIC ACID PROLINE DERIVATIVES AS HIV INHIBITORS
  申请人：HETERO RESEARCH FOUNDATION

  公开号：US20150337004A1

  公开（公告）日：2015-11-26

  The invention relates to novel betulinic acid derivatives and related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.

  本发明涉及新型苦杏仁酸衍生物和相关化合物，以及用于治疗病毒性疾病，特别是HIV介导的疾病的药物组合物。
• NOVEL BETULINIC PROLINE IMIDAZOLE DERIVATIVES AS HIV INHIBITORS
  申请人：HETERO RESEARCH FOUNDATION

  公开号：US20170129916A1

  公开（公告）日：2017-05-11

  The invention relates to novel betulinic proline substituted derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.
• US9637516B2
  申请人：——

  公开号：US9637516B2

  公开（公告）日：2017-05-02