1-ethynyl-1-hydroxy-7-methoxy-2-methyl-1,2,3,4,9,10-hexahydro-phenanthrene-2-carboxylic acid methyl ester | 872809-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 1-ethynyl-1-hydroxy-7-methoxy-2-methyl-1,2,3,4,9,10-hexahydro-phenanthrene-2-carboxylic acid methyl ester
• 英文别名: 1-Aethinyl-1-hydroxy-7-methoxy-2-methyl-1,2,3,4,9,10-hexahydro-phenanthren-2-carbonsaeure-methylester
• CAS: 872809-17-1
• 化学式: C₂₀H₂₂O₄
• 分子量: 326.392
• InChiKey: VDYHUCPPFHBXTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-ethynyl-1-hydroxy-7-methoxy-2-methyl-1,2,3,4,9,10-hexahydro-phenanthrene-2-carboxylic acid methyl ester 在 乙醇 、 氯仿 、 碘 、 铂 作用下， 生成 (+/-)-1t-ethyl-7-methoxy-2-methyl-1,2,3,4-tetrahydro-phenanthrene-2r-carboxylic acid
  参考文献：
  名称：

  Informational suppressor alleles of the eEF1A gene, fertility and cell degeneration in Podospora anserina

  摘要：

  Mutations that increase readthrough at a UGA stop codon (informational suppressor mutations) were created in the gene (AS4) that encodes translation elongation factor eEF1A in the filamentous fungus Podospora anserina. The results strongly suggest that the net charge of the eEF1A protein controls the accuracy of translation. Physiological analysis of the mutant strains shows that some of the alleles dominantly increase life span, while only one drastically modifies fertility. This exceptional allele (AS4-56) causes a wide array of phenotypes including a new growth cessation phenomenon that is different from senescence or Crippled Growth, previously known degenerative syndromes that are both controlled by AS4. The data emphasise the fact that eEF1A exerts a complex control over cellular physiology.

  DOI：

  10.1007/s004380000337
• 作为产物：
  描述：

  methyl 1,2,3,4,9,10-hexahydro-7-methoxy-2-methyl-1-oxophenanthrene-2-carboxylate 、 乙炔钠 在 乙醚 、 氨 作用下， 生成 1-ethynyl-1-hydroxy-7-methoxy-2-methyl-1,2,3,4,9,10-hexahydro-phenanthrene-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Informational suppressor alleles of the eEF1A gene, fertility and cell degeneration in Podospora anserina

  摘要：

  Mutations that increase readthrough at a UGA stop codon (informational suppressor mutations) were created in the gene (AS4) that encodes translation elongation factor eEF1A in the filamentous fungus Podospora anserina. The results strongly suggest that the net charge of the eEF1A protein controls the accuracy of translation. Physiological analysis of the mutant strains shows that some of the alleles dominantly increase life span, while only one drastically modifies fertility. This exceptional allele (AS4-56) causes a wide array of phenotypes including a new growth cessation phenomenon that is different from senescence or Crippled Growth, previously known degenerative syndromes that are both controlled by AS4. The data emphasise the fact that eEF1A exerts a complex control over cellular physiology.

  DOI：

  10.1007/s004380000337