methyl 1,2,3,4,9,10-hexahydro-7-methoxy-2-methyl-1-oxophenanthrene-2-carboxylate | 94040-36-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: methyl 1,2,3,4,9,10-hexahydro-7-methoxy-2-methyl-1-oxophenanthrene-2-carboxylate
• 英文别名: 7-methoxy-2-methyl-1-oxo-1,2,3,4,9,10-hexahydro-phenanthrene-2-carboxylic acid methyl ester；7-Methoxy-2-methyl-1-oxo-1,2,3,4,9,10-hexahydro-phenanthren-2-carbonsaeure-methylester；Methyl 7-methoxy-2-methyl-1-oxo-3,4,9,10-tetrahydrophenanthrene-2-carboxylate
• CAS: 94040-36-5
• 化学式: C₁₈H₂₀O₄
• 分子量: 300.354
• InChiKey: RVAKYIUFDWMFMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 1,2,3,4,9,10-hexahydro-7-methoxy-2-methyl-1-oxophenanthrene-2-carboxylate 在 乙醚 、 乙醇 、 氨 、 铂 作用下， 生成 1-ethyl-1-hydroxy-7-methoxy-2-methyl-1,2,3,4,9,10-hexahydro-phenanthrene-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Informational suppressor alleles of the eEF1A gene, fertility and cell degeneration in Podospora anserina

  摘要：

  Mutations that increase readthrough at a UGA stop codon (informational suppressor mutations) were created in the gene (AS4) that encodes translation elongation factor eEF1A in the filamentous fungus Podospora anserina. The results strongly suggest that the net charge of the eEF1A protein controls the accuracy of translation. Physiological analysis of the mutant strains shows that some of the alleles dominantly increase life span, while only one drastically modifies fertility. This exceptional allele (AS4-56) causes a wide array of phenotypes including a new growth cessation phenomenon that is different from senescence or Crippled Growth, previously known degenerative syndromes that are both controlled by AS4. The data emphasise the fact that eEF1A exerts a complex control over cellular physiology.

  DOI：

  10.1007/s004380000337
• 作为产物：
  描述：

  methyl 1,2,3,4,9,10-hexahydro-1-hydroxy-2-methyl-7-methoxyphenanthrene-2-carboxylate 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醚 为溶剂， 以79.9%的产率得到methyl 1,2,3,4,9,10-hexahydro-7-methoxy-2-methyl-1-oxophenanthrene-2-carboxylate
  参考文献：
  名称：

  Narasimhan, Nurani S.; Bapat, Chintamani P., Journal of the Chemical Society. Perkin transactions I, 1984, # 7, p. 1435 - 1439

  摘要：

  DOI：

文献信息

• Sunder, Nurani M.; Patil, Prakash A.; Narasimhan, Nurani S., Journal of the Chemical Society. Perkin transactions I, 1990, # 5, p. 1331 - 1334
  作者：Sunder, Nurani M.、Patil, Prakash A.、Narasimhan, Nurani S.

  DOI：——

  日期：——
• The Synthesis of 1,3,5-Estratrien-3-ol-16-one, A Structural Isomer of Estrone¹
  作者：A. L. Wilds、Thomas L. Johnson

  DOI：10.1021/ja01183a085

  日期：1948.3
• Beschichtung von Sitzsystemen auf Vordermann gebracht
  作者：Matthias Horber

  DOI：10.1007/bf03251062

  日期：2002.12
• Synthetic Sterols. III.¹ Isomers of 1-Ethyl-2-methyl-7-methoxy-1,2,3,4,9,10,11,12- octahydrophenanthrene-2-carboxylic Acid
  作者：James H. Hunter、John A. Hogg

  DOI：10.1021/ja01174a007

  日期：1949.6
• Stoutamire,D.W., Diss. <Univ. of Wisconsin 1957> S. 29, 100
  作者：Stoutamire,D.W.

  DOI：——

  日期：——