Et-EDTA | 56982-82-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Et-EDTA
• 英文别名: EDTA N,N'-dimethyl ester；2-[2-[carboxymethyl-(2-methoxy-2-oxoethyl)amino]ethyl-(2-methoxy-2-oxoethyl)amino]acetic acid
• CAS: 56982-82-2
• 化学式: C₁₂H₂₀N₂O₈
• mdl: MFCD00187858
• 分子量: 320.299
• InChiKey: ABHLVHFTQWZGRH-UHFFFAOYSA-N

物化性质

• 沸点：
  493.7±45.0 °C(Predicted)
• 密度：
  1.349±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.2
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  Et-EDTA 、 胱氨酸二甲酯 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.5h， 以63%的产率得到
  参考文献：
  名称：

  The trans opening of ethylene diamine tetra acetic acid bis anhydride (EDTAA) with cystine-di-OMe: one-step synthesis of bihelical systems

  摘要：

  The generation of a bihelical (figure of 8) motif has been illustrated by trans opening of EDTAA with L-cystine-di-OMe and D-penicillamine disulfide-di-OMe. In the former case the open cyclic system, arising by cis addition, was secured as a minor product. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.11.078
• 作为产物：
  描述：

  甲醇 、 乙二胺四乙酸二酐 反应 24.0h， 以98%的产率得到Et-EDTA
  参考文献：
  名称：

  The trans opening of ethylene diamine tetra acetic acid bis anhydride (EDTAA) with cystine-di-OMe: one-step synthesis of bihelical systems

  摘要：

  The generation of a bihelical (figure of 8) motif has been illustrated by trans opening of EDTAA with L-cystine-di-OMe and D-penicillamine disulfide-di-OMe. In the former case the open cyclic system, arising by cis addition, was secured as a minor product. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.11.078

文献信息

• Chelants and macrocyclic metal complex radiopharmaceuticals thereof
  申请人：Liu Shuang

  公开号：US20050010038A1

  公开（公告）日：2005-01-13

  Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as radiopharmaceuticals for the diagnosis of cardiovascular disorders, infectious diseases and cancer are also disclosed. Chelants as bifunctional chelators (BFCs) for the radiolabeling of target-specific biomolecules, such as proteins, peptides, peptidomimetics, non-peptide receptor ligands, enzyme inhibitors, and enzyme substrates are disclosed. Methods of using macrocyclic metal complexes containing the chelant-biomolecule conjugates as target-specific diagnostic radiopharmaceuticals that selectively localize at sites of disease and allow an image to be obtained of the loci using gamma scintigraphy are disclosed. Methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders, such as thromboembolic disease or atherosclerosis, infectious disease and cancer are further disclosed.

  螯合剂及其大环金属配合物，制备螯合剂和大环金属配合物的方法，以及包括大环金属配合物的放射性药物组合物被揭示。还揭示了将大环金属配合物用作用于诊断心血管疾病、传染病和癌症的放射性药物的方法。揭示了作为靶向特定生物分子（如蛋白质、肽、肽类似物、非肽受体配体、酶抑制剂和酶底物）的放射标记的双功能螯合剂（BFCs）的螯合剂。揭示了使用含有螯合剂-生物分子共轭物的大环金属配合物作为靶向特定诊断放射性药物的方法，这些药物选择性地定位于疾病部位，并允许使用伽马闪烁术获得部位的图像。进一步揭示了将放射性药物用作心血管疾病（如血栓栓塞病或动脉粥样硬化）、传染病和癌症的诊断成像剂的方法。
• BIODEGRADABLE POLYANHYDRIDES WITH NATURAL BIOACTIVE MOLECULES
  申请人：Rutgers, The State University of New Jersey

  公开号：EP2146701B1

  公开（公告）日：2013-10-16
• US8747832B2
  申请人：——

  公开号：US8747832B2

  公开（公告）日：2014-06-10
• [EN] BIODEGRADABLE POLYANHYDRIDES WITH NATURAL BIOACTIVE MOLECULES<br/>[FR] POLYANHYDRIDES BIODÉGRADABLES AVEC MOLÉCULES BIOACTIVES NATURELLES
  申请人：UNIV RUTGERS

  公开号：WO2008128193A1

  公开（公告）日：2008-10-23

  [EN] The invention provides polymers that include a biologically active molecule and methods for their use.
  [FR] L'invention porte sur des polymères comprenant une molécule biologiquement active et sur les procédés d'utilisation les concernant.
• [EN] ANTI-INFLAMMATORY COMPOSITIONS AND METHODS<br/>[FR] COMPOSITIONS ANTI-INFLAMMATOIRES ET MÉTHODES ASSOCIÉES
  申请人：RR MEDSCIENCES PTY LTD

  公开号：WO2020154762A1

  公开（公告）日：2020-08-06

  Disclosed are compositions comprising a copper complex useful in the reduction of inflammation in one or more tissues. Also disclosed are methods of utilizing the copper complexes for treating/preventing inflammation in one or more tissues, treating/ enhancing wound healing, preventing/reducing DNA damage caused by radiation, and reducing free radical damage.