[4-(7-methoxy-2,2-dimethylchroman-4-ylidenemethyl)phenyl]dimethylamine | 1072933-33-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: [4-(7-methoxy-2,2-dimethylchroman-4-ylidenemethyl)phenyl]dimethylamine
• 英文别名: 4-[(7-methoxy-2,2-dimethyl-3H-chromen-4-ylidene)methyl]-N,N-dimethylaniline
• CAS: 1072933-33-5
• 化学式: C₂₁H₂₅NO₂
• 分子量: 323.435
• InChiKey: VNMXJPQTVXPNTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4-dimethylaminophenyl)-(7-methoxy-2,2-dimethyl-2H-chromen-4-yl)methanol 在 三溴化磷 作用下， 以 苯 为溶剂， 以67%的产率得到[4-(7-methoxy-2,2-dimethylchroman-4-ylidenemethyl)phenyl]dimethylamine
  参考文献：
  名称：

  An unexpected reaction of phosphorous tribromide on chromanone, thiochromanone, 3,4-dihydro-2H-benzo[b]thiepin-5-one, 3,4-dihydro-2H-benzo[b]oxepin-5-one and tetralone derived allylic alcohols: a case study

  摘要：

  Treatment of chromanone, thiochromanone, tetralone and benzo[b]thiepinone derived allylic alcohols with phosphorous tribromide furnished unexpected products instead of desired bromo derivatives. Reaction of 7-methoxy-2,2-dimethylchromenyl-aryl-methanols and 7-methoxy-2,2-dimethylthio-chromenyl-aryl-methanols with PBr3 gave saturated carbonyls and exocyclic olefins depending on the substituents at R-4, whereas allylic alcohols without 7-methoxy substituent furnished rearranged products. Several related analogs varying in ring size, heteroatom in the ring and substituents at various positions were synthesized and studied. Reactions of other phosphorous-based reagents like PPh3, PPh3/I-2 and PPh3Br2 on allylic alcohols were also attempted. A case study is presented here. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.106