L-phenylalanyl-L-phenylalanine ethyl ester trifluoroacetate | 83671-02-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-phenylalanyl-L-phenylalanine ethyl ester trifluoroacetate
• CAS: 83671-02-7
• 化学式: C₂HF₃O₂*C₂₀H₂₄N₂O₃
• 分子量: 454.446
• InChiKey: AEIRNIZTXLAATM-APTPAJQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.48
• 重原子数：
  32.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  118.72
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  L-phenylalanyl-L-phenylalanine ethyl ester trifluoroacetate 在 吡啶 、 2C₁₁H₁₉O₂^(1-)*Co⁽²⁺⁾ 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 silver carbonate 、 三甲基乙酸 作用下， 以 N,N-二甲基甲酰胺 、 氯苯 为溶剂， 20.0~120.0 ℃ 、101.33 kPa 条件下， 反应 25.0h， 生成 、 ethyl (1-oxo-1,2-dihydroisoquinoline-3-carbonyl)-L-phenylalaninate
  参考文献：
  名称：

  钴催化的氨基酸 C(sp2)-H 羰基化使用吡啶甲酰胺作为无痕导向基团

  摘要：

  在此，我们报告了一种基于廉价钴 (II) 盐催化剂的氨基酸衍生物C(sp 2 )-H 羰基化的有效方案。羰基化是使用吡啶甲酰胺作为无痕导向基团、CO (1 atm) 作为羰基源和 Co(dpm) 2作为催化剂来完成的。广泛的带有不同官能团的苯丙氨酸衍生物是可以耐受的。此外，该方法可成功应用于短肽的 C(sp 2 )-H 羰基化，从而允许进行肽后期羰基化。

  DOI：

  10.1021/acs.orglett.1c00660
• 作为产物：
  描述：

  Boc-Phe-OH*DCHA 在 N,N'-二环己基碳二亚胺 作用下， 生成 L-phenylalanyl-L-phenylalanine ethyl ester trifluoroacetate
  参考文献：
  名称：

  Structures of L-phenylalanine dimers, N-(tert-butoxycarbonyl)-L-phenylalanyl-L-phenylalanine benzyl ester (Boc-Phe-Phe-OBzl) and L-phenylalanyl-L-phenylanine ethyl ester trifluoroacetate (Phe-Phe-OEt.Tfa)

  摘要：

  DOI：

  10.1107/s0567740882009522

文献信息

• Varying the hydrophobic spacer to influence multicomponent gelation
  作者：Santanu Panja、Bart Dietrich、Adriana Trabold、Agata Zydel、Aleena Qadir、Dave J. Adams

  DOI：10.1039/d1cc02786g

  日期：——

  We investigate the effect of hydrophobic spacer on gel properties in a multicomponent system.

  我们研究了疏水间隔对多组分体系中凝胶性质的影响。
• Efficient and Highly Selective Copper(II) Transport across a Bulk Liquid Chloroform Membrane Mediated by Lipophilic Dipeptides
  作者：Marco C. Cleij、Paolo Scrimin、Paolo Tecilla、Umberto Tonellato

  DOI：10.1021/jo9703257

  日期：1997.8.1

  Several structurally simple N-monoalkylated and -dialkylated dipeptides made of alpha-amino acids Gly, Phe, and Leu, 1-11, were synthesized and investigated as carriers for the transport of Cu(II), Zn(II), and Ni(II) from an aqueous pH = 5.6 buffer source to a 0.1 M HCl receiving phase across a bulk chloroform membrane. The proton-driven translocation was followed during the process by analyzing the metal ion concentrations in the three phases. The transport efficiency depends on the ease of formation of a neutral complex with Cu(II) (the peptide group and carboxylic acid being deprotonated) at the source-chloroform interface and on that of its disruption by protonation at the receiving phase: the carrier's Lipophilicity favors the metal ion uptake and not the release. By modulating the length of the N-alkyl chains and the hydrophobicity of the dipeptide moiety, a quite remarkable transport efficiency was observed for Cu(II), in most cases superior to that of the industrial extractant Kelex 100. Moreover, using L,L- and L,D-N-octyl-PheLeu as carriers, remarkable diastereomeric effects were observed in the rate of uptake and release of Cu(II) ion although the differences mutually compensate in the overall transport rate. Under the conditions used the carriers are much less effective in the translocation of Zn(II) and Ni(II) and their transport efficiency drops dramatically in the presence of Cu(II), the latter being favored by factors of 1.2 x 10(3) and > 10(4), respectively. Such very high selectivities depend on the fact that only Cu(II) among other transition metal ions Can form neutral complexes at the pH value of the source phase.