2-(2-(2-(4-tritylphenoxy)acetamido)acetamido)acetic acid | 954418-74-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-(2-(4-tritylphenoxy)acetamido)acetamido)acetic acid
• 英文别名: 2-[[2-[[2-(4-Tritylphenoxy)acetyl]amino]acetyl]amino]acetic acid
• CAS: 954418-74-7
• 化学式: C₃₁H₂₈N₂O₅
• 分子量: 508.574
• InChiKey: HKDDNBWAWGTXFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(5'-Methoxy-3',3'-dimethyl-6-nitrospiro[chromene-2,2'-indole]-1'-yl)ethyl 2-chloroacetate 、 2-(2-(2-(4-tritylphenoxy)acetamido)acetamido)acetic acid 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以65%的产率得到[2-[2-(5'-Methoxy-3',3'-dimethyl-6-nitrospiro[chromene-2,2'-indole]-1'-yl)ethoxy]-2-oxoethyl] 2-[[2-[[2-(4-tritylphenoxy)acetyl]amino]acetyl]amino]acetate
  参考文献：
  名称：

  Photoisomerization of Spiropyran for Driving a Molecular Shuttle

  摘要：

  A novel light-powered molecular shuttle was synthesized which can switch the movement of a macrocycle between two distinct stations-dipeptide and zwitterionic ME-by exploiting the photoisomerization of spiropyran. The macrocycle resides selectively in the dipeptide station in the SP form and moves to the ME station under the irradiation of UV light. This movement process of the macrocycle is accompanied by reversible absorptive output signals which can be detected by the naked eye.

  DOI：

  10.1021/ol7015862
• 作为产物：
  描述：

  ethyl 2-(2-(2-(4-tritylphenoxy)acetamido)acetamido)acetate 在 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 12.0h， 以96%的产率得到2-(2-(2-(4-tritylphenoxy)acetamido)acetamido)acetic acid
  参考文献：
  名称：

  Photoisomerization of Spiropyran for Driving a Molecular Shuttle

  摘要：

  A novel light-powered molecular shuttle was synthesized which can switch the movement of a macrocycle between two distinct stations-dipeptide and zwitterionic ME-by exploiting the photoisomerization of spiropyran. The macrocycle resides selectively in the dipeptide station in the SP form and moves to the ME station under the irradiation of UV light. This movement process of the macrocycle is accompanied by reversible absorptive output signals which can be detected by the naked eye.

  DOI：

  10.1021/ol7015862