o-anisole | 1072120-50-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: o-anisole
• CAS: 1072120-50-3
• 化学式: C₁₇H₁₅NO₃
• 分子量: 281.311
• InChiKey: ZJTWEHRHNAIRMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  47.89
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  o-anisole 、 N-(2E,4E)-hexadienoylpyrrole 在 (3S,5S,8S)-2,2,7,7-tetrakis(4-fluorophenyl)-4,9-dimethyl-3,8-bis(2-methylpropyl)-1,4,6,9-tetraza-5lambda5-phosphaspiro[4.4]non-1(5)-ene 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以91%的产率得到
  参考文献：
  名称：

  Highly Regio-, Diastereo-, and Enantioselective 1,6- and 1,8-Additions of Azlactones to Di- and Trienyl N-Acylpyrroles

  摘要：

  A vinylog of Michael addition (1,6-addition) of azlactones to delta-substituted dienyl N-acylpyrroles been developed with virtually complete 1,6-diastereo-, and enantioselectivities by means of chiral P-spiro triaminoiminophosphorane as a catalyst. This system has been successfully extended to an unprecedented bis-vinylog of Michael addition (1,8 addition) of azlactones to zeta-substituted trienyl N-acylpyrroles with high levels of regio- and stereocontrol.

  DOI：

  10.1021/ja310209g

文献信息

• Chiral Tetraaminophosphonium Carboxylate-Catalyzed Direct Mannich-Type Reaction
  作者：Daisuke Uraguchi、Yusuke Ueki、Takashi Ooi

  DOI：10.1021/ja806311e

  日期：2008.10.29

  The cooperative asymmetric catalysis of chiral tetraaminophosphonium carboxylate (P,S)-1-OCOR has been established, and its synthetic utility has been successfully demonstrated by application to the highly enantioselective direct Mannich-type reaction of azlactones with N-sulfonyl imines. The present study stimulates the cultivation of the potential of the chiral quaternary onium salt catalysis by the structural modification of organic anion.