(3S,5S,8S)-2,2,7,7-tetrakis(4-fluorophenyl)-4,9-dimethyl-3,8-bis(2-methylpropyl)-1,4,6,9-tetraza-5lambda5-phosphaspiro[4.4]non-1(5)-ene | 1412898-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,5S,8S)-2,2,7,7-tetrakis(4-fluorophenyl)-4,9-dimethyl-3,8-bis(2-methylpropyl)-1,4,6,9-tetraza-5lambda5-phosphaspiro[4.4]non-1(5)-ene
• 英文别名: (3S,5S,8S)-2,2,7,7-tetrakis(4-fluorophenyl)-4,9-dimethyl-3,8-bis(2-methylpropyl)-1,4,6,9-tetraza-5λ5-phosphaspiro[4.4]non-1(5)-ene
• CAS: 1412898-94-2
• 化学式: C₃₈H₄₃F₄N₄P
• 分子量: 662.754
• InChiKey: OGZZUIFNSNQNIQ-ILGGSYKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  47
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  30.9
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  在 盐酸 、 ammonium formate 、 三乙胺 、 锌 、 三氯化磷 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 19.0h， 生成 (3S,5S,8S)-2,2,7,7-tetrakis(4-fluorophenyl)-4,9-dimethyl-3,8-bis(2-methylpropyl)-1,4,6,9-tetraza-5lambda5-phosphaspiro[4.4]non-1(5)-ene
  参考文献：
  名称：

  Highly Regio-, Diastereo-, and Enantioselective 1,6- and 1,8-Additions of Azlactones to Di- and Trienyl N-Acylpyrroles

  摘要：

  A vinylog of Michael addition (1,6-addition) of azlactones to delta-substituted dienyl N-acylpyrroles been developed with virtually complete 1,6-diastereo-, and enantioselectivities by means of chiral P-spiro triaminoiminophosphorane as a catalyst. This system has been successfully extended to an unprecedented bis-vinylog of Michael addition (1,8 addition) of azlactones to zeta-substituted trienyl N-acylpyrroles with high levels of regio- and stereocontrol.

  DOI：

  10.1021/ja310209g
• 作为试剂：
  描述：

  4-苄基-2-苯基-2-噁唑啉-5-酮 、 N-(2E,4E)-hexadienoylpyrrole 在 (3S,5S,8S)-2,2,7,7-tetrakis(4-fluorophenyl)-4,9-dimethyl-3,8-bis(2-methylpropyl)-1,4,6,9-tetraza-5lambda5-phosphaspiro[4.4]non-1(5)-ene 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以94%的产率得到
  参考文献：
  名称：

  Highly Regio-, Diastereo-, and Enantioselective 1,6- and 1,8-Additions of Azlactones to Di- and Trienyl N-Acylpyrroles

  摘要：

  A vinylog of Michael addition (1,6-addition) of azlactones to delta-substituted dienyl N-acylpyrroles been developed with virtually complete 1,6-diastereo-, and enantioselectivities by means of chiral P-spiro triaminoiminophosphorane as a catalyst. This system has been successfully extended to an unprecedented bis-vinylog of Michael addition (1,8 addition) of azlactones to zeta-substituted trienyl N-acylpyrroles with high levels of regio- and stereocontrol.

  DOI：

  10.1021/ja310209g

文献信息

• Highly Regio-, Diastereo-, and Enantioselective 1,6- and 1,8-Additions of Azlactones to Di- and Trienyl <i>N</i>-Acylpyrroles
  作者：Daisuke Uraguchi、Ken Yoshioka、Yusuke Ueki、Takashi Ooi

  DOI：10.1021/ja310209g

  日期：2012.11.28

  A vinylog of Michael addition (1,6-addition) of azlactones to delta-substituted dienyl N-acylpyrroles been developed with virtually complete 1,6-diastereo-, and enantioselectivities by means of chiral P-spiro triaminoiminophosphorane as a catalyst. This system has been successfully extended to an unprecedented bis-vinylog of Michael addition (1,8 addition) of azlactones to zeta-substituted trienyl N-acylpyrroles with high levels of regio- and stereocontrol.