N-异丙基-1H-吡唑-1-甲酰胺 | 93605-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: N-异丙基-1H-吡唑-1-甲酰胺
• 英文名称: Pyrazole-1-carboxylic acid isopropylamide
• 英文别名: N-Isopropyl-1H-pyrazole-1-carboxamide；N-propan-2-ylpyrazole-1-carboxamide
• CAS: 93605-71-1
• 化学式: C₇H₁₁N₃O
• mdl: MFCD18809515
• 分子量: 153.184
• InChiKey: QVKDMPTXYAPPIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吡唑 、 异氰酸异丙酯 以 乙醚 为溶剂， 反应 3.0h， 以59%的产率得到N-异丙基-1H-吡唑-1-甲酰胺
  参考文献：
  名称：

  氨基酸衍生的潜在异氰酸酯：猪胰弹性蛋白酶和人白细胞弹性蛋白酶的不可逆失活。

  摘要：

  已经合成了几种氨基酸衍生的偶氮内酯（I），并研究了它们对人白细胞弹性蛋白酶和猪胰弹性蛋白酶的抑制活性。发现抑制活性取决于前体氨基酸酯的性质。因此，发现衍生自L-缬氨酸甲酯3，L-正缬氨酸甲酯5，DL-正亮氨酸甲酯9和L-甲硫氨酸甲酯10的化合物不可逆地抑制两种酶。发现化合物10是人白细胞弹性蛋白酶的特异性和选择性抑制剂。与这些相反，发现衍生自甘氨酸甲酯1，D-缬氨酸甲酯4和D-去甲缬氨酸甲酯6的抑制剂是无活性的。

  DOI：

  10.1021/jm00380a010

文献信息

• N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS
  申请人：Konradi Andrei W.

  公开号：US20100081680A1

  公开（公告）日：2010-04-01

  The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R 25 , R 50 , and R 51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.

  当前发明提供具有根据公式1、2、3和4结构的化合物：其中A环、B环、C环、m、n、R25、R50和R51如说明书所述。该发明还提供了包含公式1、2、3和4化合物的药物组合物，以及治疗认知障碍的方法，如阿尔茨海默病。该发明进一步提供了用于制备公式1、2、3和4化合物的有用的中间体。
• HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1458379A1

  公开（公告）日：2004-09-22
• US7488752B2
  申请人：——

  公开号：US7488752B2

  公开（公告）日：2009-02-10
• US8283358B2
  申请人：——

  公开号：US8283358B2

  公开（公告）日：2012-10-09
• [EN] HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] DERIVES D'HYDROXYPHENYL-PYRAZOLE SERVANT D'INHIBITEURS DE KINASE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2003051358A1

  公开（公告）日：2003-06-26

  The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof and effective amount of o-hydroxy phenyl-pyrazol-3-yl derivatives optionally substituted of formula (I). The invention also provides some new compounds, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.