Ethyl 2-[4-[4,6,10,12,16,18,22,24-octakis(2-ethoxy-2-oxoethoxy)-8,14,20-tris[4-(2-ethoxy-2-oxoethoxy)phenyl]-2-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3(28),4,6,9(27),10,12,15,17,19(26),21,23-dodecaenyl]phenoxy]acetate | 830329-32-3

• 分子结构分类: 有机化合物
• 英文名称: Ethyl 2-[4-[4,6,10,12,16,18,22,24-octakis(2-ethoxy-2-oxoethoxy)-8,14,20-tris[4-(2-ethoxy-2-oxoethoxy)phenyl]-2-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3(28),4,6,9(27),10,12,15,17,19(26),21,23-dodecaenyl]phenoxy]acetate
• CAS: 830329-32-3
• 化学式: C₁₀₀H₁₁₂O₃₆
• 分子量: 1889.97
• InChiKey: UVPFYWZHPGZKFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.6
• 重原子数：
  136
• 可旋转键数：
  64
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  426
• 氢给体数：
  0
• 氢受体数：
  36

反应信息

• 作为反应物：
  描述：

  Ethyl 2-[4-[4,6,10,12,16,18,22,24-octakis(2-ethoxy-2-oxoethoxy)-8,14,20-tris[4-(2-ethoxy-2-oxoethoxy)phenyl]-2-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3(28),4,6,9(27),10,12,15,17,19(26),21,23-dodecaenyl]phenoxy]acetate 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以85%的产率得到2-[4-[4,6,10,12,16,18,22,24-Octakis(2-hydrazinylidene-2-hydroxyethoxy)-8,14,20-tris[4-(2-hydrazinylidene-2-hydroxyethoxy)phenyl]-2-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3(28),4,6,9(27),10,12,15,17,19(26),21,23-dodecaenyl]phenoxy]ethanehydrazonic acid
  参考文献：
  名称：

  Syntheses, crystal structures, and electrochemical properties of multi-ferrocenyl resorcinarenes

  摘要：

  Tetraaryl and tetraferrocenyl resorcinarenes 1a-1c have been synthesized by the HCl-catalyzed condensation of resorcinol with aromatic aldehydes or ferrocenecarbaldehyde, which were fully alkylated with ethyl a-chloroacetate to give the activated ethyl resorcinarylacetates 2a-2c. Reaction of 2a-2c with hydrated hydrazine yielded the resorcinarene acylhydrazine derivatives 3a-3c, from which the multi-ferrocenyl functional groups were selectively and efficiently introduced on the upper rim, or on the lower rim, or both on the upper and lower rims of resorcinarenes 4a-4c and calixarenes 4d-4f based upon the condensation reactions of acylhydrazones with ferrocenecarboxaldehyde. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.12.073
• 作为产物：
  描述：

  2,8,14,20-tetrakis(4-hydroxyphenyl)pentacyclo-[19.3.1.1^3,7.1^15,19]octacosal(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-4,6,10,12,16,18,22,24-octol 、 氯乙酸乙酯 在 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 168.0h， 以56.5%的产率得到Ethyl 2-[4-[4,6,10,12,16,18,22,24-octakis(2-ethoxy-2-oxoethoxy)-8,14,20-tris[4-(2-ethoxy-2-oxoethoxy)phenyl]-2-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3(28),4,6,9(27),10,12,15,17,19(26),21,23-dodecaenyl]phenoxy]acetate
  参考文献：
  名称：

  Syntheses, crystal structures, and electrochemical properties of multi-ferrocenyl resorcinarenes

  摘要：

  Tetraaryl and tetraferrocenyl resorcinarenes 1a-1c have been synthesized by the HCl-catalyzed condensation of resorcinol with aromatic aldehydes or ferrocenecarbaldehyde, which were fully alkylated with ethyl a-chloroacetate to give the activated ethyl resorcinarylacetates 2a-2c. Reaction of 2a-2c with hydrated hydrazine yielded the resorcinarene acylhydrazine derivatives 3a-3c, from which the multi-ferrocenyl functional groups were selectively and efficiently introduced on the upper rim, or on the lower rim, or both on the upper and lower rims of resorcinarenes 4a-4c and calixarenes 4d-4f based upon the condensation reactions of acylhydrazones with ferrocenecarboxaldehyde. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.12.073

文献信息

• Synthesis of Thiourea‐Bridged Cluster Glycoside Calixarenes
  作者：Yun Ge、Yahua Cai、Chaoguo Yan

  DOI：10.1080/00397910500187548

  日期：2005.9.1

  Abstract Thiourea‐bridged peracetylated glycoside calixarenes have been smoothly synthesized by the addition reactions of tetraacetylglycosyl isothiocyanates with amidoamine derivatives of calix[4]resorcinarene and p‐tert‐butylcalix[n]arenas (n=6, 8) in high yields (40–75%). All the glycoside‐containing calixarenes were characterized by 1H NMR, IR spectroscopy, and elemental analysis.

  摘要 通过四乙酰糖基异硫氰酸酯与杯[4]间苯二酚的酰胺胺衍生物和对叔丁基杯[n]arenas (n=6, 8) 的加成反应，硫脲桥连的过乙酰化杯芳烃以高产率 (40– 75%）。所有含糖苷的杯芳烃均通过 1H NMR、IR 光谱和元素分析进行​​表征。
• Synthesis of Novel Chemically Amplified Materials Based on Calix[4]arene Derivatives with Acetal Moieties
  作者：Hiroto Kudo、Kouji Mitani、Syuhei Koyama、Tadatomi Nishikubo

  DOI：10.1246/bcsj.77.2109

  日期：2004.11

  The synthesis and photoinduced deprotection reaction of calix[4]resorcinarene derivatives with pendant acetal moieties were examined. C-methyl[(methoxymethylcarbonyl)oxy]calix[4]resorcinarene (CRA-Acetal) and C-4-hydroxyphenyl[(methoxymethylcarbonyl)oxy]calix[4]resorcinarene (CRAph-Acetal) were prepared from C-methylcalix[4]resorcinarene (CRA) and C-4-hydroxyphenylcalix[4]resorcinarene (CRAph). The synthesized CRA-Acetal and CRAph-Acetal had good solubilities, good film-forming properties, and high thermal stabilities. The photoinduced deprotection reaction of CRA-Acetal and CRAph-Acetal was examined in the presence of bis[4-(diphenylsulfonio)phenyl]sulfide (DPSP) as a photo-acid generator in the film state upon UV irradiation. It was found that the deprotection reaction of acetal groups of CRA-Acetal and CRAph-Acetal proceeded smoothly without further heating to produce the corresponding calixarene derivatives, CRA-COOH and CRAph-COOH with carboxylic acid groups.

  研究了带有乙缩醛侧基的杯[4]萘并芘衍生物的合成和光诱导脱保护反应。通过C-甲基杯[4]萘并芘（CRA）和C-4-羟基苯基杯[4]萘并芘（CRAph）制备了C-甲基[(甲氧基甲基羰基)氧基]杯[4]萘并芘（CRA-乙缩醛）和C-4-羟基苯基[(甲氧基甲基羰基)氧基]杯[4]萘并芘（CRAph-乙缩醛）。合成的CRA-乙缩醛和CRAph-乙缩醛具有良好的溶解性、成膜性和热稳定性。在双[4-(二苯基硫鎓)苯基]硫醚（DPSP）作为光酸产生剂存在的情况下，研究了CRA-乙缩醛和CRAph-乙缩醛的光诱导脱保护反应。研究发现，CRA-乙缩醛和CRAph-乙缩醛的乙缩醛基团的脱保护反应顺利进行，无需进一步加热即可生成相应的带有羧酸基团的杯芳烃衍生物CRA-COOH和CRAph-COOH。
• Ge, Yun; Yan, Chaoguo, Journal of Chemical Research, 2004, # 4, p. 279 - 281
  作者：Ge, Yun、Yan, Chaoguo

  DOI：——

  日期：——