6-phenylhexane-1,5-diol | 1265632-29-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-phenylhexane-1,5-diol
• CAS: 1265632-29-8
• 化学式: C₁₂H₁₈O₂
• 分子量: 194.274
• InChiKey: NDSNINBRBMJEPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-phenylhexane-1,5-diol 在 二苯基环丙烯酮 、 甲基磺酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 以89%的产率得到2-benzyltetrahydropyran
  参考文献：
  名称：

  Cyclopropenium-Activated Cyclodehydration of Diols

  摘要：

  The dehydrative cyclization of diols to cyclic ethers via cyclopropenium activation is described. Using 2,3-diphenylcyclopropene and methanesulfonic anhydride, a series of 1,4- and 1,5-diols are rapidly cyclized to furnish tetrahydrofurans and tetrahydropyrans in high yield. Eleven total substrates are shown, including a gram scale cyclization of a diterpene derivative.

  DOI：

  10.1021/ol102980t
• 作为产物：
  描述：

  1-苯基-5-己烯-2-醇 在 咪唑 、 硼烷四氢呋喃络合物 、 4-甲基苯磺酸吡啶 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 17.08h， 生成 6-phenylhexane-1,5-diol
  参考文献：
  名称：

  Cyclopropenium-Activated Cyclodehydration of Diols

  摘要：

  The dehydrative cyclization of diols to cyclic ethers via cyclopropenium activation is described. Using 2,3-diphenylcyclopropene and methanesulfonic anhydride, a series of 1,4- and 1,5-diols are rapidly cyclized to furnish tetrahydrofurans and tetrahydropyrans in high yield. Eleven total substrates are shown, including a gram scale cyclization of a diterpene derivative.

  DOI：

  10.1021/ol102980t

文献信息

• One-Pot Sequential 1,4- and 1,2-Reductions of α,β-Unsaturated δ-Lactones to the Corresponding δ-Lactols with CuCl and NaBH4 in Methanol
  作者：Yasunobu Matsumoto、Masahiro Yonaga

  DOI：10.1055/s-0033-1340195

  日期：——

  An efficient, one-pot method for the highly chemoselective synthesis of δ-lactols from α,β-unsaturated δ-lactones using CuCl and NaBH4 in methanol was developed.

  开发了一种高效的一锅法，用于在甲醇中使用 CuCl 和 NaBH4 从 α,β-不饱和 δ-内酯高度化学选择性地合成 δ-内酯。
• Rhodium‐Catalyzed Remote Borylation of Alkynes and Vinylboronates
  作者：Minghao Zhang、Zheming Liu、Wanxiang Zhao

  DOI：10.1002/anie.202215455

  日期：2023.1.26

  of internal alkynes and sterically hindered tri- and tetra-substituted vinylboronates enabled by rhodium catalysis is reported. The 1,n-diboronate products can be converted to a variety of useful building blocks, biologically active molecules, and drugs via the selective manipulation of the two boryl groups in products including the regioselective cross coupling, oxidation, and amination.

  报道了通过铑催化实现的内部炔烃和空间位阻三取代和四取代乙烯基硼酸盐的区域选择性远程硼化。1, n-二硼酸酯产品可以通过对产品中两个硼基的选择性操作（包括区域选择性交叉偶联、氧化和胺化）转化为各种有用的结构单元、生物活性分子和药物。
• iRNA agents targeting VEGF
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：EP2365077A1

  公开（公告）日：2011-09-14

  The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically modified.

  本发明的特征涉及用于调节血管内皮生长因子（VEGF）表达的化合物、组合物和方法，例如通过 RNA 干扰（RNAi）机制。这些化合物和组合物包括可未经修饰或经化学修饰的 iRNA 制剂。
• IRNA agents targeting VEGF
  申请人：Fougerolles De Antonin

  公开号：US20060223770A1

  公开（公告）日：2006-10-05

  The features of the present invention relate to compounds, compositions and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compounds and compositions include iRNA agents that can be unmodified or chemically-modified.

  本发明的特征涉及用于调节血管内皮生长因子（VEGF）表达的化合物、组合物和方法，例如通过 RNA 干扰（RNAi）机制。本发明的化合物和组合物包括未经修饰或化学修饰的 iRNA 制剂。
• iRNA AGENTS TARGETING VEGF
  申请人：Alnylam Pharmaceuticals Inc.

  公开号：EP1735009A2

  公开（公告）日：2006-12-27