5-iodo-1-(β-D-lyxofuranosyl)uracil | 86258-61-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-iodo-1-(β-D-lyxofuranosyl)uracil
• 英文别名: 1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
• CAS: 86258-61-9
• 化学式: C₉H₁₁IN₂O₆
• 分子量: 370.101
• InChiKey: RKSLVDIXBGWPIS-FZGKIIIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-iodo-1-(β-D-lyxofuranosyl)uracil 在 N-氯代丁二酰亚胺 、 sodium methylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 6,2':6,5'-dianhydro-5,5-dichloro-5,6-dihydro-6,6-dihydroxy-1-(β-D-lyxofuranosyl)uracil
  参考文献：
  名称：

  Halogenation of pyrimidine 6-O-cyclonucleosides

  摘要：

  DOI：

  10.1021/jo00164a016
• 作为产物：
  描述：

  uridine 在 碘 、 硝酸 作用下， 以 氯仿 为溶剂， 反应 1.5h， 以86%的产率得到5-iodo-1-(β-D-lyxofuranosyl)uracil
  参考文献：
  名称：

  Halogenation of pyrimidine 6-O-cyclonucleosides

  摘要：

  DOI：

  10.1021/jo00164a016

文献信息

• DEVICES, COMPOSITIONS AND METHODS FOR IMAGING WITH RAMAN SCATTERING
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20160243261A1

  公开（公告）日：2016-08-25

  Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.

  本发明公开了使用受激拉曼散射成像活体细胞或活体生物的键编辑化合物的方法、系统和计算机可访问介质。该方法包括将一个或多个键编辑化合物引入活体细胞或活体生物，并使用受激拉曼散射检测细胞或生物中的振动标记。本发明还公开了检测受试者疾病状况的方法、监测疾病状况治疗的方法、筛选试剂的方法、使用键编辑化合物与受激拉曼散射相结合追踪活体细胞中的细胞过程的方法。本发明还公开了一种用至少一个键编辑化合物标记目标细胞的组合物以及用受激拉曼散射成像键编辑化合物的设备。
• DEVICES, COMPOSITIONS AND METHODS FOR IMAGING WITH RAMAN SCATTERING AND FOR SUPER-MULTIPLEX VIBRATIONAL IMAGING
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20210068663A1

  公开（公告）日：2021-03-11

  Exemplary methods, systems and computer-accessible medium for detecting at least one condition of at least one disease. In particular, it is possible to administer at least one composition to at least one patient, where the at least one composition includes at least one bond-edited compound configured to target at least one of a disease tissue or a pathogen. Further, it is possible to receive information related to the administration of the composition to the patient. It is also possible to detect the at least one bond-edited compound using a Raman scattering arrangement.
• [EN] MODULATORS OF DUX4 FOR REGULATION OF MUSCLE FUNCTION<br/>[FR] MODULATEURS DE DUX4 POUR LA RÉGULATION DE LA FONCTION MUSCULAIRE
  申请人：GENEA IP HOLDINGS PTY LTD

  公开号：WO2017201585A1

  公开（公告）日：2017-11-30

  Disclosed herein are methods and compositions for the treatment of facioscapulohumeral muscular dystrophy and other muscle diseases or disorders. In some cases, the methods and compositions involve the use of methyltransferase inhibitors to inhibit or repress DUX4 expression in muscle cells. Further disclosed herein are methods and cell based assays for screening compounds for the treatment of facioscapulohumeral muscular dystrophy and other muscle diseases.