4-iodoethynyl-1,3-dimethyl-1H-pyrazole | 72804-26-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-iodoethynyl-1,3-dimethyl-1H-pyrazole
• 英文别名: 4-(2-Iodoethynyl)-1,3-dimethylpyrazole
• CAS: 72804-26-3
• 化学式: C₇H₇IN₂
• 分子量: 246.05
• InChiKey: BMMRKNIBNMFNIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-iodoethynyl-1,3-dimethyl-1H-pyrazole 、 氨基钠 以100%的产率得到
  参考文献：
  名称：

  SINYAKOV A. N.; SHVARTSBERG M. S., IZV. AN CCCP. CEP. XIM., 1979, HO 10, 2306-2312

  摘要：

  DOI：
• 作为产物：
  描述：

  4-乙炔基-1,3-二甲基吡唑 以85%的产率得到
  参考文献：
  名称：

  SINYAKOV A. N.; SHVARTSBERG M. S., IZV. AN CCCP. CEP. XIM., 1979, HO 10, 2306-2312

  摘要：

  DOI：

文献信息

• Fused pyrimidine compound or salt thereof
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US10807986B2

  公开（公告）日：2020-10-20

  The problem to be solved by the present invention is to provide a novel compound having RET inhibitory activity. The present invention also provides a pharmaceutical preparation that is useful for the prevention and/or treatment of RET-related diseases, particularly cancer, based on RET inhibitory activity. The present invention provides a compound represented by Formula (I): wherein A, R2, and X are as defined in the specification; or a salt thereof.

  本发明要解决的问题是提供一种具有 RET 抑制活性的新型化合物。本发明还提供了一种基于 RET 抑制活性的药物制剂，可用于预防和/或治疗 RET 相关疾病，特别是癌症。本发明提供了一种由式（I）表示的化合物： 其中 A、R2 和 X 如说明书中所定义；或其盐。
• NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20190330214A1

  公开（公告）日：2019-10-31

  The problem to be solved by the present invention is to provide a novel compound having RET inhibitory activity. The present invention also provides a pharmaceutical preparation that is useful for the prevention and/or treatment of RET-related diseases, particularly cancer, based on RET inhibitory activity. The present invention provides a compound represented by Formula (I): wherein A, R 2 , and X are as defined in the specification; or a salt thereof.