2-methoxy-enanthic acid methyl ester | 36122-32-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methoxy-enanthic acid methyl ester
• 英文别名: 2-Methoxy-oenanthsaeure-methylester；Methyl 2-methoxyheptanoate；methyl 2-methoxyheptanoate
• CAS: 36122-32-4
• 化学式: C₉H₁₈O₃
• 分子量: 174.24
• InChiKey: VIOXFGXJURNMCU-UHFFFAOYSA-N

物化性质

• 沸点：
  224.3±13.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxy-enanthic acid methyl ester 在 甲酸 、 乙醚 作用下， 生成 正戊基异丙基甲酮
  参考文献：
  名称：

  Darzens; Levy, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1933, vol. 196, p. 187

  摘要：

  DOI：
• 作为产物：
  描述：

  sodium methylate 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-methoxy-enanthic acid methyl ester
  参考文献：
  名称：

  Darzens; Levy, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1933, vol. 196, p. 187

  摘要：

  DOI：

文献信息

• Coadministration of Tacrolimus and Mycophenolate Mofetil in Stable Kidney Transplant Patients: Pharmacokinetics and Tolerability
  作者：John Pirsch、Ihor Bekersky、Flavio Vincenti、Garry Boswell、E. Steve Woodle、Ala Alak、Margaret Kruelle、Nancy Fass、David Facklam、Qais Mekki

  DOI：10.1177/00912700022009143

  日期：2000.5

  The tolerance and pharmacokinetics (PK) of tacrolimus (T) by the addition of mycophenolate mofetil (MMF) in stable kidney transplant patients (6/group) on long-term tacrolimus-based therapy were investigated. Patients received combination T and MMF therapy at three MMF doses: 1, 1.5, and 2 g/day administered twice daily. A 12-hour blood PK profile for T was obtained prior to MMF dosing; concomitant 12-hour profiles for T, mycophenolic acid (MPA), and mycophenolic acid glucuronide (MPAG) were obtained after 2 weeks of administration. Tolerance was monitored through 3 months. The intra- and intergroup PK of T were variable. The mean AUC0–12 of T for each group was increased after 2 weeks of concomitant MMF administration, but the increase was not statistically significant. Both drugs were well tolerated. Gastrointestinal events were of interest as such have been attributed to both T and MMF. Events reported were diarrhea, nausea, dyspepsia, and vomiting. Other common adverse events were headache, hypomagnesemia, and tremors. Most were mild, although a few were considered to be moderate. There was no apparent relationship between the incidence of any adverse event and MMF treatment group. In the present study, the coadministration of T and MMF did not significantly alter T pharmacokinetics.

  研究了长期接受他克莫司治疗的稳定肾移植患者（6 人/组）在他克莫司（T）基础上添加霉酚酸酯（MMF）的耐受性和药代动力学（PK）。患者在三种 MMF 剂量下接受 T 和 MMF 联合疗法：每天 1 克、1.5 克和 2 克，每天给药两次。在 MMF 给药前检测 T 的 12 小时血液 PK 曲线；给药 2 周后检测 T、霉酚酸 (MPA) 和霉酚酸葡萄糖醛酸苷 (MPAG) 的同时 12 小时曲线。对耐受性的监测持续了 3 个月。T的组内和组间PK各不相同。同时服用 MMF 2 周后，各组 T 的平均 AUC0-12 均有所增加，但增加幅度无统计学意义。两种药物的耐受性均良好。由于 T 和 MMF 均可引起胃肠道事件，因此胃肠道事件值得关注。报告的事件有腹泻、恶心、消化不良和呕吐。其他常见的不良反应有头痛、低镁血症和震颤。大多数不良反应是轻微的，但也有少数被认为是中度的。任何不良反应的发生率与 MMF 治疗组之间均无明显关系。在本研究中，同时服用 T 和 MMF 不会显著改变 T 的药代动力学。
• SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：Theravance, Inc.

  公开号：EP1556372A2

  公开（公告）日：2005-07-27
• [EN] SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL)PIPERIDINE AND RELATED COMPOUNDS<br/>[FR] 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE SUBSTITUEE ET COMPOSES ASSOCIES
  申请人：THERAVANCE INC

  公开号：WO2004041806A2

  公开（公告）日：2004-05-21

  This invention provides 4-amino-1-(pyridylmethyl) piperidine of formula (I) and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.
• Darzens; Levy, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1933, vol. 196, p. 187
  作者：Darzens、Levy

  DOI：——

  日期：——