cobalt(II) tetramethylhematoporphyrin | 71068-60-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: cobalt(II) tetramethylhematoporphyrin
• 英文别名: cobalt(II) gematoporphyrin；Co(II) tetramethylhematoporphyrin
• CAS: 71068-60-5
• 化学式: C₃₈H₄₄CoN₄O₆
• 分子量: 711.784
• InChiKey: CLXKIPBVLVWKGW-VEOPCBELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  N-亚硝基降烟碱 、 cobalt(II) tetramethylhematoporphyrin 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  The interaction of a cobalt porphyrin with cancer-associated nitrosamines

  摘要：

  A cobalt porphyrin (CY-B) was presented, and its interaction with tobacco-specific nitrosamines (TSNAs) was investigated by UV-Vis spectroscopy and high-resolution mass spectrometry. The results revealed that the stoichiometry of the host-guest interaction was 1:2 and that the binding constant between CY-B and TSNAs was within the range of 0.78×10(8)-7.83×10(8)M(-2). The coordination strength between CY-B and TSNAs decreased in the sequence of NNN>NAB>NAT>NNK based on the binding constant. The interaction mechanism of CY-B with TSNAs involved a coordination interaction, and the π-π interaction between the porphyrin macrocycle and the aromatic frame of the TSNAs pyridines may also have been a driving force. The measured thermodynamic properties demonstrated that the reaction of CY-B with TSNAs was spontaneous and that the driving force for the interaction was a change in enthalpy. The reaction was exothermic, and an increasing temperature inhibited the interaction. The IR spectrum of the complex revealed that the NNO group of TSNAs and the metal cobalt of CY-B formed the six-coordinate complex.

  DOI：

  10.1016/j.bioorg.2014.07.007
• 作为产物：
  描述：

  tetramethyl hematoporphyrine 、 cobalt(II) chloride 以 溶剂黄146 为溶剂， 生成 cobalt(II) tetramethylhematoporphyrin
  参考文献：
  名称：

  Haurowitz, F.; Clar, E.; Hermann, Z., Chemische Berichte, 1935, vol. 68, p. 1795 - 1806

  摘要：

  DOI：

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Co: SVol.B1, 25, page 53 - 55
  作者：

  DOI：——

  日期：——
• Kinetics of the metal-exchange reaction of deuteroporphyrin and gematoporphyrin cadmium complexes with cobalt chloride in acetonitrile
  作者：S. V. Zvezdina、M. B. Berezin、B. D. Berezin

  DOI：10.1134/s0036023607080177

  日期：2007.8

  The metal-exchange reaction of cadmium deuteroporphyrin (CdDP) and cadmium gematoporphyrin (CdGP) with cobalt chloride in acetonitrile is studied spectrophotometrically. The stoichiometry of the metal-exchange reaction is determined. The results are compared with the exchange reaction of cadmium mesoporphyrin and cadmium protoporphyrin with cobalt acetate in acetonitrile. Substituents in the 2,4-positions of cadmium complexes of protoporphyrins are shown to influence the rate of the metal-exchange reaction. The increasing order of the rates of the metal-exchange reaction between protoporphyrins and cobalt chloride in acetonitrile is established.