methyl (2S)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanamido]propanoate | 240418-72-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanamido]propanoate
• 英文别名: 3-(4-hydroxy-phenyl)-2-[3-(4-hydroxy-phenyl)-propionylamino]-propionic acid methyl ester；methyl (2S)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanoylamino]propanoate
• CAS: 240418-72-8
• 化学式: C₁₉H₂₁NO₅
• 分子量: 343.379
• InChiKey: WZHOWGULCGRQCS-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl (2S)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanamido]propanoate 在 4-二甲氨基吡啶 、 potassium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 2.25h， 生成 2-[(2S)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanoylamino]propanoyl]oxyethyl 2-methylprop-2-enoate
  参考文献：
  名称：

  BIOCOMPOSITIONS FOR 3D PRINTING

  摘要：

  本公开涉及树脂以及由此形成的聚合物、共聚物和混合物。

  公开号：

  US20190100489A1
• 作为产物：
  描述：

  对羟基苯丙酸 、 L-酪氨酸甲酯盐酸盐 在 三乙胺 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 以54%的产率得到methyl (2S)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanamido]propanoate
  参考文献：
  名称：

  BIOCOMPOSITIONS FOR 3D PRINTING

  摘要：

  本公开涉及树脂以及由此形成的聚合物、共聚物和混合物。

  公开号：

  US20190100489A1

文献信息

• FUNCTIONALIZED DIPHENOLICS AND ABSORBABLE POLYMERS THEREFROM
  申请人：Bezwada S Rao

  公开号：US20070135355A1

  公开（公告）日：2007-06-14

  The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

  本发明涉及去酚化合物，以下是一个示例，这些化合物被官能化，并且形成的聚合物。从官能化二酚形成的聚合物预计具有可控的降解特性，使它们能够在所需的时间范围内释放活性成分。这些聚合物也预计在各种医疗应用中有用。
• PHENYL-CONTAINING N-ACYL AMINE AND AMINOACID DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, A PHARMACEUTICAL COMPOSITION AND THE USE THEREOF
  申请人：Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises"

  公开号：EP1876169A1

  公开（公告）日：2008-01-09

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.

  本发明涉及作为环氧化酶抑制剂的通式（I）生物胺和氨基酸的新型苯基-N-酰基衍生物，该衍生物具有镇痛和抗炎特性，无副作用，特别是无溃疡性和促痉挛作用，并能增强其他镇痛药的效果，此外还具有抗缺氧、抗抑郁和抗帕金森病作用；以及生物胺的新型和已知苯基-N-酰基衍生物的制备工艺、药物组合物和包含通式（I）化合物的制剂及其用途和治疗方法。
• Biocompositions for 3D printing
  申请人：3D-Biomaterials, LLC

  公开号：US10781166B2

  公开（公告）日：2020-09-22

  The present disclosure is directed to resins and to polymers, copolymers, and blends formed therefrom.

  本公开涉及树脂及其形成的聚合物、共聚物和混合物。
• Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof
  申请人：Nebolsin Vladimir Evgenievich

  公开号：US20090111874A1

  公开（公告）日：2009-04-30

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.
• PHENYL-N-ACYL DERIVATIVES OF AMINES AND AMINO ACIDS, A PROCESS FOR THE PREPARATION THEREOF, A PHARMACEUTICAL COMPOSITION AND USE THEREOF
  申请人：Obschestvo S Ogranichennoi Otvetstvennostiyu

  公开号：US20130109880A1

  公开（公告）日：2013-05-02

  The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-spasmodic actions, as well as capability to potentiate effect of other analgetics, and possessing in addition antihypoxic, antidepressant and anti-Parkinsonistic action; as well as to the processes for the preparation novel and known phenyl-N-acyl derivatives of biogenic amines, to a pharmaceutical composition and to an agent comprising compounds of general formula (I) as well as to use thereof and a method of treating.