4-甲氧基水杨酸钾

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-甲氧基水杨酸钾
• 中文别名: 甲氧基肉桂酸钾；4-甲氧基水杨酸钾盐
• 英文名称: potassium 4-methoxysalicylate
• 英文别名: Potassium;2-carboxy-5-methoxyphenolate；potassium;2-carboxy-5-methoxyphenolate
• 化学式: C₈H₇O₄*K
• 分子量: 206.239
• InChiKey: YRJKYHIIYRGTCC-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.23
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-甲氧基水杨酸钾 、 (2-氯甲基)-5-羟基-4H-吡喃-4-酮 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-hydroxy-4-methoxybenzoic acid 5-hydroxy-4-oxo-4H-pyran-2-ylmethyl ester
  参考文献：
  名称：

  Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities

  摘要：

  We synthesized benzoate ester derivatives of kojic acid with and without adamantane moiety. Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities. However, depigmenting activity was not noted in a cell-based assay. Contrasting results were obtained for benzoate derivatives (3a-e) containing an adamantane moiety. Compounds 3a-e showed potent depigmenting activities without tyrosinase inhibitory activities. To the best of our knowledge, this is the first study showing the depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2012.04.046
• 作为产物：
  描述：

  甲醇 、 2,4-二羟基苯甲酸 在 sodium methylate 、 对甲苯磺酸甲酯 作用下， 反应 2.0h， 以83.3%的产率得到4-甲氧基水杨酸钾
  参考文献：
  名称：

  一种4-甲氧基水杨酸的合成方法

  摘要：

  本发明属于有机化学合成技术领域，公开一种4‑甲氧基水杨酸的合成方法。所述方法包括下述步骤：(1)制备反应：将2,4‑二羟基苯甲酸加入甲醇钠的甲醇溶液，再滴加对甲苯磺酸甲酯并搅拌反应液；(2)蒸馏：对步骤(1)得到的反应液进行蒸馏，除去甲醇；(3)酸化：将步骤(2)得到的反应液倒入加有盐酸的冰水混合物中，并搅拌；(4)过滤和清洗：过滤步骤(3)得到的混合液，并用水清洗，得到4‑甲氧基水杨酸粗品。用微毒的对甲苯磺酸甲酯替代剧毒的硫酸二甲酯，并以甲醇钠为催化剂，副产物少，制备过程简单，产生的废水少，污染轻，制备的4‑甲氧基水杨酸纯度高，收率大。

  公开号：

  CN109293497A

文献信息

• GLYCERYL ASCORBIC ACID ACYLATED DERIVATIVE OR ITS SALT, PRODUCTION METHOD THEREOF, AND COSMETICS
  申请人：YOSHIOKA Masato

  公开号：US20130204017A1

  公开（公告）日：2013-08-08

  A glyceryl ascorbic acid acylated derivative or its salt, which has an ascorbic acid structure where 2- and/or 3-positions of the structure are substituted with glyceryl groups and some of the hydroxyl groups in the structure and/or in the glyceryl group are acylated, a production method of the glyceryl ascorbic acid acylated derivative and a cosmetic containing the glyceryl ascorbic acid acylated derivative or its salt are provided.

  提供一个甘油抗坏血酸酰化衍生物或其盐，其具有抗坏血酸结构，其中2-和/或3-位被甘油基团取代，并且结构中的一些羟基和/或甘油基团被酰化，提供甘油抗坏血酸酰化衍生物的生产方法，以及包含甘油抗坏血酸酰化衍生物或其盐的化妆品。
• 4-Alkylresorcinol Derivative And External Preparation For Skin Containing The Same
  申请人：Fukunishi Hirotada

  公开号：US20130109878A1

  公开（公告）日：2013-05-02

  The present invention provides a compound that has a high whitening effect and is excellent in safety and stability and provides an external preparation for skin comprising the same. The compound of the present invention is a 4-alkylresorcinol derivative represented by formula (1) or a salt thereof: wherein R 1 is a branched or cyclic alkyl group of 3 to 7 carbon atoms or a linear alkyl group of 2 to 5 carbon atoms; R 2 and R 3 are each independently a hydrogen atom or a group represented by —P(O)(OR 4 )(OR 5 ), and at least one of R 2 and R 3 is a group represented by —P(O)(OR 4 )(OR 5 ); and R 4 and R 5 are each independently a hydrogen atom or a linear or branched alkyl group of 2 to 5 carbon atoms.

  本发明提供了一种具有高美白效果、安全稳定性优异的化合物，并提供了包括该化合物的皮肤外用制剂。本发明的化合物是一种4-烷基间苯二酚衍生物，其化学式表示为（1）或其盐：其中，R1是由3至7个碳原子组成的支链或环烷基，或由2至5个碳原子组成的直链烷基；R2和R3各自独立地是氢原子或由—P(O)(OR4)(OR5)表示的基团，且R2和R3中至少一个是由—P(O)(OR4)(OR5)表示的基团；R4和R5各自独立地是氢原子或由2至5个碳原子组成的直链或支链烷基。
• GLUCURONOLACTONE DERIVATIVES AS SELF-TANNING SUBSTANCES
  申请人：MERCK PATENT GMBH

  公开号：US20160008253A1

  公开（公告）日：2016-01-14

  The invention relates to the use of specific glucuronolactone derivatives as self-tanning substances, as tanning enhancers for dihydroxyacetone or for a mixture of self-tanning substances comprising dihydroxyacetone, for modulation of the hue achieved in the case of tanning with dihydroxyacetone or by the mixture or preparation comprising dihydroxyacetone, as contrast-reduction agents or for colouring keratin-containing fibres, and to preparations or compositions for colouring keratin-containing fibres comprising these specific glucuronolactone derivatives.

  本发明涉及使用特定葡萄糖醛酸内酯衍生物作为自日晒剂、作为增强二羟基乙酮或含二羟基乙酮的自日晒剂混合物的日晒效果的调节剂、作为降低对比度的剂或用于染色角蛋白质含量纤维的染料，以及包含这些特定葡萄糖醛酸内酯衍生物的角蛋白质含量纤维染料的制剂或组合物。
• SUBSTITUTED QUINONES OR ANALOGUES AS COLOURING AGENTS
  申请人：MERCK PATENT GMBH

  公开号：US20150315177A1

  公开（公告）日：2015-11-05

  The invention relates to protein-adhesive dyes, to the preparation thereof and to preparations comprising same, and to a method for colouring keratin-containing fibres, in particular for colouring human hair.

  本发明涉及蛋白质黏合染料及其制备和制备物，以及一种用于着色含角蛋白纤维的方法，特别是用于着色人类头发的方法。
• EXTRACT POWDER OF INDIGO PLANT, AND ITS PREPARATION AND USES
  申请人：Fujii Mitsukiyo

  公开号：US20100034757A1

  公开（公告）日：2010-02-11

  The present invention has objects to provide an extract powder of indigo plant, which has a relatively low hygroscopicity, satisfactory fluidability, and improved storage stability; a process thereof; and a composition incorporated with the extract powder. The objects are solved by a process for producing an extract powder of indigo plant, which comprises incorporating a partial starch hydrolyzate with a dextrose equivalent of 10.2 or lower into one part by weight, on a dry solid basis, of an indigo plant extract contained in a liquid extract of indigo plant in an amount of not lower than 0.25 part by weight but not higher than 5 parts by weight, on a dry solid basis, and drying the resulting mixture; an extract powder of indigo plant prepared thereby; and a composition incorporated with the extract powder.

  本发明旨在提供一种靛蓝植物的提取粉末，其具有相对较低的吸湿性、满意的流动性和改善的储存稳定性；其制备方法；以及与提取粉末混合的组合物。通过将DE值为10.2或更低的部分淀粉水解物以不低于0.25份重量但不高于5份重量的干固物基础加入到液态提取的靛蓝植物提取物的一份重量中，并将所得混合物干燥，来解决上述问题；由此制备的靛蓝植物提取粉末；以及与提取粉末混合的组合物。