4-(5-chloro-benzoxazol-2-yl)-N-((1R,3S)-3-ethylcarbamoyl-cyclopentyl)-N-methyl-benzamide | 1610513-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(5-chloro-benzoxazol-2-yl)-N-((1R,3S)-3-ethylcarbamoyl-cyclopentyl)-N-methyl-benzamide
• 英文别名: 4-(5-chloro-1,3-benzoxazol-2-yl)-N-[(1R,3S)-3-(ethylcarbamoyl)cyclopentyl]-N-methylbenzamide
• CAS: 1610513-88-6
• 化学式: C₂₃H₂₄ClN₃O₃
• 分子量: 425.915
• InChiKey: SSYOXERIUWHSRY-FUHWJXTLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  75.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] N-(MONOCYCLIC ARYL),N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS<br/>[FR] COMPOSÉS DE N-ARYLE MONOCYCLIQUES, N'-PYRAZOLYL-URÉE, THIOURÉE, GUANIDINE ET CYANOGUANIDINE UTILES COMME INHIBITEURS DE TRKA KINASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2014078325A1

  公开（公告）日：2014-05-22

  Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

  化合物的公式(I)或其立体异构体、互变异构体、或其药学上可接受的盐、溶剂合物或前药，其中环A、环C和X如本文所定义，是TrkA激酶的抑制剂，并且在治疗可以用TrkA激酶抑制剂治疗的疾病中具有用处，如疼痛、癌症、炎症/炎症性疾病、神经退行性疾病、某些传染病、干燥综合征、子宫内膜异位症、糖尿病周围神经病变、前列腺炎或盆腔疼痛综合征。
• [EN] 3-AMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES<br/>[FR] DÉRIVÉS DE 3-AMINOCYCLOPENTANE CARBOXAMIDE
  申请人：MERCK PATENT GMBH

  公开号：WO2014075754A1

  公开（公告）日：2014-05-22

  Compounds of the formula (I) in which R1, R4, R, X1, X2, X3, X4, q and W have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

  式（I）中R1、R4、R、X1、X2、X3、X4、q和W的含义如权利要求1所示，是脂肪酸合成酶的抑制剂，可用于治疗癌症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。
• 3-AMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES
  申请人：MERCK PATENT GMBH

  公开号：US20160264517A1

  公开（公告）日：2016-09-15

  Compounds of the formula I in which R 1 , R 4 , R, X 1 , X 2 , X 3 , X 4 , q and W have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

  式子I中，R1、R4、R、X1、X2、X3、X4、q和W的含义如权利要求书1所示，是脂肪酸合酶的抑制剂，可用于治疗癌症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。
• US9732032B2
  申请人：——

  公开号：US9732032B2

  公开（公告）日：2017-08-15