1,2-bis(4-iodophenoxy)ethane | 117934-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,2-bis(4-iodophenoxy)ethane
• 英文别名: (p-IC6H4OCH2)2；1-Iodo-4-[2-(4-iodophenoxy)ethoxy]benzene
• CAS: 117934-82-4
• 化学式: C₁₄H₁₂I₂O₂
• 分子量: 466.057
• InChiKey: HXPWHRNDZMLZKQ-UHFFFAOYSA-N

物化性质

• 熔点：
  175-177 °C
• 沸点：
  472.6±40.0 °C(Predicted)
• 密度：
  1.922±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (pentafluoropropenyl)tri-n-butyltin 、 1,2-bis(4-iodophenoxy)ethane 在 copper(l) iodide 、 四(三苯基膦)钯 作用下， 以 四氢呋喃 为溶剂， 以52%的产率得到(CF3CF=CFC6H4OCH2)2
  参考文献：
  名称：

  Pentafluoropropenyl Complexes of Mercury, Germanium, Tin, and Lead Derived from (Z)-CFH═CFCF₃and Their Use as Transfer Reagents

  摘要：

  A series of new (E)-pentafluoropropenyl complexes of Hg, Ge, Sn, and Pb are reported derived from CFH=CFCF3 ((Z)-HFC-1225ye). Unequivocal assignment of the geometry of the products was achieved via a multinuclear (H-1, C-13, F-19, Sn-119, and Hg-199) NMR study. These conclusions are confirmed in the single-crystal X-ray structures of Ph3Ge(CF=CFCF3) and Ph3Sn(CF=CFCF3). In the solid-state structures of both molecules, short contacts are observed between one of the fluorine atoms of the CF3 group and the metal center. The Bu3Sn(CF=CFCF3) compound acts as an effective source of the pentafluoropropenyl group in a series of palladium-catalyzed Stille-Liebeskind reactions to generate new aryl-pentafluoropropenyl systems.

  DOI：

  10.1021/om2009843
• 作为产物：
  描述：

  1,2-二苯氧基乙烷 在 N,N,N-trimethylbenzenemethanaminium dichloroiodate 、 zinc(II) chloride 作用下， 以 溶剂黄146 为溶剂， 反应 4.0h， 以95%的产率得到1,2-bis(4-iodophenoxy)ethane
  参考文献：
  名称：

  用苄基三甲基二氯碘酸铵和氯化锌碘化芳醚

  摘要：

  在氯化锌存在下，在室温下，芳香醚与二氯碘酸苄基铵 (1-) 在乙酸中反应，得到碘取代的芳香醚，收率良好。

  DOI：

  10.1246/cl.1988.795

文献信息

• Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques
  作者：Jianhua Jia、Longfei Zhang、Jia Song、Jiapei Dai、Mengchao Cui

  DOI：10.1021/acs.molpharmaceut.0c00537

  日期：2020.11.2

  analysis revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development

  具有 π 共轭系统的高度刚性和平面支架已被广泛认为是 β-淀粉样蛋白 (Aβ) 结合配体必不可少的。在这项研究中，合成并评估了具有不同类型的更灵活的接头作为 Aβ 配体的二苯氧基化合物库。它们中的大多数对 Aβ 1-42聚集体显示出良好的亲和力 ( K i < 100 nM) ，一些配体甚至显示出K i值小于 10nM。构效关系分析表明，接头或取代基的修饰具有很大的灵活性，这挑战了长期以来认为刚性和平面结构专用于 Aβ 结合的观点。三种配体被碘125标记，它们在体外和体内表现出良好的特性，进一步支持这种柔性支架在Aβ成像剂的开发中具有潜力和前景。
• <i>In Situ</i> Generation of Azonia-Containing Polyelectrolytes for Luminescent Photopatterning and Superbug Killing
  作者：Xiaolin Liu、Mengge Li、Ting Han、Bing Cao、Zijie Qiu、Yuanyuan Li、Qiyao Li、Yubing Hu、Zhiyang Liu、Jacky W. Y. Lam、Xianglong Hu、Ben Zhong Tang

  DOI：10.1021/jacs.9b04757

  日期：2019.7.17

  Polyelectrolytes play an important role in both natural biological systems and human society, and their synthesis, functional exploration, and profound application are thus essential for biomimicry and creating new materials. In this study, we developed an efficient synthetic methodology for in situ generation of azonia-containing polyelectrolytes in a one-pot manner by using readily accessible nonionic reactant in the presence of commercially available cheap ionic species. The resulting polyelectrolytes are emissive in the solid state and can readily form luminescent photopatterns with different colors. The azonia-containing polyelectrolytes possess extraordinary potency of reactive oxygen species (ROS) generation, enabling them to impressively kill methicillin-resistant Staphylococcus aureus (MRSA), a drug resistant superbug, both in vitro and in vivo.
• KAJIGAESHI, SHOJI;KAKINAMI, TAKAAKI;MORIWAKI, MASAYUKI;WATANABE, MASAKAZU+, CHEM. LETT.,(1988) N 5, 795-798
  作者：KAJIGAESHI, SHOJI、KAKINAMI, TAKAAKI、MORIWAKI, MASAYUKI、WATANABE, MASAKAZU+

  DOI：——

  日期：——