methyl 1-(4-methoxyphenyl)-4-((4-methoxyphenyl)amino)-2,6-diphenyl-1,2,5,6-tetrahydropyridine-3-carboxylate | 1261054-23-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物
• 英文名称: methyl 1-(4-methoxyphenyl)-4-((4-methoxyphenyl)amino)-2,6-diphenyl-1,2,5,6-tetrahydropyridine-3-carboxylate
• 英文别名: methyl 4-(4-methoxyphenylamino)-1,2,5,6-tetrahydro-1-(4-methoxyphenyl)-2,6-diphenylpyridine-3-carboxylate；methyl 4-(4-methoxyanilino)-1-(4-methoxyphenyl)-2,6-diphenyl-3,6-dihydro-2H-pyridine-5-carboxylate
• CAS: 1261054-23-2
• 化学式: C₃₃H₃₂N₂O₄
• 分子量: 520.628
• InChiKey: YRPZJOIIPNAWGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  60
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 trans-5-hydroperoxy-3,5-dimethyl-1,2-dioxolane-3-yl ethaneperoxate 、 potassium hydroxide 作用下， 以 氯仿 、 水 为溶剂， 以70 %的产率得到methyl 1-(4-methoxyphenyl)-4-((4-methoxyphenyl)amino)-2,6-diphenyl-1,2,5,6-tetrahydropyridine-3-carboxylate
  参考文献：
  名称：

  利用反式-5-氢过氧-3,5-二甲基-1,2-二氧戊环-3-基乙过氧酸酯生成的单线态氧，将硫代酰胺和硫代酮方便地转化为其氧类似物

  摘要：

  报道了一种用单线态氧将硫代酰胺和硫酮氧化转化为其氧类似物的有效方法。单线态氧是由碎片原位产生的...

  DOI：

  10.1080/17415993.2024.2337841

文献信息

• N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis
  作者：James Sherwood、Helen L. Parker、Kristof Moonen、Thomas J. Farmer、Andrew J. Hunt

  DOI：10.1039/c6gc00932h

  日期：——

  N-Butylpyrrolidinone (NBP) has been demonstrated as a suitable safer replacement solvent for N-Methylpyrrolidinone (NMP) in selected organic syntheses.

  Ñ -Butylpyrrolidinone（NBP）已被证明是合适的更安全的替代溶剂Ñ在选定的有机合成甲基吡咯烷酮（NMP）。
• Multicomponent preparation of highly functionalized piperidines using magnesium hydrogen sulfate as an efficient catalyst
  作者：Mohammad Reza Mohammad Shafiee、Batool Hojati Najafabadi、Majid Ghashang

  DOI：10.1007/s11164-012-0878-1

  日期：2013.10

  Abstract A simple, highly versatile, and efficient synthesis of functionalized piperidines is achieved by four-component cyclo-condensation of aldehydes, aromatic amines, and acetoacetic esters using magnesium hydrogen sulfate [Mg(HSO4)2] as a catalyst in acetonitrile as the solvent at room temperature. The key advantages of this procedure are high yields, easy work-up, and purification of products

  摘要 以硫酸氢镁[Mg（HSO 4）2 ]为催化剂，通过乙醛，芳族胺和乙酰乙酸酯的四组分环缩合反应，可以简单，高效地合成官能化哌啶。在室温下的溶剂。该方法的主要优点是高产率，易于后处理和通过非色谱法纯化产物。 图形概要
• Cerium Ammonium Nitrate-Catalyzed Multicomponent Reaction for Efficient Synthesis of Functionalized Tetrahydropyridines
  作者：Hong-Juan Wang、Li-Ping Mo、Zhan-Hui Zhang

  DOI：10.1021/co100055x

  日期：2011.3.14

  A highly atom-economic one-pot synthesis of functionalized tetrahydropyridines by a multicomponent condensation reaction of β-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of cerium ammonium nitrate (CAN) is reported. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate

  据报道，在催化量的硝酸铈铵（CAN）存在下，β-酮酸酯，两当量的芳族醛和两当量的胺的多组分缩合反应可实现原子经济的一锅法合成功能化四氢吡啶。 。以这种方式，在室温下以中等至良好的产率获得了一系列药理学上有趣的取代的哌啶衍生物。
• SULFAMIC ACID CATALYZED FIVE COMPONENT REACTION FOR EFFICIENT AND ONE-POT SYNTHESIS OF DENSELY FUNCTIONALIZED TETRAHYDROPYRIDINE SCAFFOLD
  作者：ANIKETP SARKATE、JAIPRAKASH N SANGSHETTI、NANASAHEB B DHARBALE、AJINKYA P SARKATE、DEVANAND B SHINDE

  DOI：10.4067/s0717-97072015000100012

  日期：——

  acid in One-pot assembling of aromatic aldehydes, aromatic amines and β-keto esters to afford densely functionalized tetrahydropyridines in 70-89% yield has been presented. The advantage of sulfamic acid against other catalysts in terms of yield has been studied. The effect of different solvents on reaction time and yield has also been studied. Easy work up and mild reaction condition are the advantages

  已经提出了氨基磺酸在芳族醛，芳族胺和β-酮酯的一锅组装中以70-89％的产率提供致密官能化的四氢吡啶的用途。研究了氨基磺酸相对于其他催化剂在产率方面的优势。还研究了不同溶剂对反应时间和产率的影响。该方法的优点是易于后处理，反应条件温和。
• Synthesis of tetrahydropyridines by one-pot multicomponent reaction using nano-sphere silica sulfuric acid
  作者：Masoume Daraei、Mohammad Ali Zolfigol、Fateme Derakhshan-Panah、Morteza Shiri、Hendrik G. Kruger、Mohammad Mokhlesi

  DOI：10.1007/s13738-014-0548-x

  日期：2015.5

  A highly efficient protocol for the synthesis of 1,2,3,4-tetrahydropyridines in the presence of nano-sphere silica sulfuric acid (NS-SSA) was used for good yields by one-pot multicomponent reaction (MCRs). The reagent nano-sphere silica sulfuric acid (NS-SSA) has several advantages, such as easy workup, nontoxicity, convenience and high yields of products.

  通过一锅多组分反应（MCR），在纳米球二氧化硅硫酸（NS-SSA）存在下合成1,2,3,4-四氢吡啶的高效方法用于获得良好的收率。该试剂纳米球二氧化硅硫酸盐（NS-SSA）具有后处理容易，无毒，方便，收率高等优点。