2(2-hydroxy-5-ethylphenyl)2H-benzotriazole | 13303-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2(2-hydroxy-5-ethylphenyl)2H-benzotriazole
• 英文别名: 2-(2'-Hydroxy-5'-ethylphenyl)benzotriazole；2-(benzotriazol-2-yl)-4-ethylphenol
• CAS: 13303-98-5
• 化学式: C₁₄H₁₃N₃O
• 分子量: 239.277
• InChiKey: NAHKJPXTQGGPSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-Ethyl-2-(2-nitro-phenylazo)-phenol 在 sodium hydroxide 作用下， 以 异丙醇 为溶剂， 反应 24.0h， 以87%的产率得到2(2-hydroxy-5-ethylphenyl)2H-benzotriazole
  参考文献：
  名称：

  Photostimulated Reductive Cyclization of o-Nitrophenylazo Dyes Using Sodium Hydroxide in Isopropyl Alcohol. A New Synthesis of 2-Aryl-2H-benzotriazoles

  摘要：

  o-Nitrophenylazo dyes with NaOH were irradiated in isopropyl alcohol to give the corresponding benzotriazoles. The photostimulated reductive cyclization proceeds through the formation of N-oxides as an intermediate.

  DOI：

  10.3987/com-99-8597

文献信息

• [EN] WATER-SOLUBLE UV-ABSORBING COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HYDROSOLUBLES ABSORBANT LES UV ET LEURS UTILISATIONS
  申请人：NOVARTIS AG

  公开号：WO2017093835A1

  公开（公告）日：2017-06-08

  Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV- absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

  本文描述了含有二甲基缩醛的吸收紫外线化合物及其在制备适用于生产能够阻挡紫外线（"UV"）辐射和可选地（但最好）波长为380纳米至440纳米的紫外线吸收聚乙烯醇预聚合物的紫外线吸收接触镜中的用途，从而在一定程度上保护眼睛免受紫外线辐射和潜在的紫外辐射造成的损害。本发明还提供了一种吸收紫外线的聚乙烯醇预聚合物。
• TOPICAL AGENT FOR DERMATOLOGICAL USE
  申请人：Nakayama Hiroki

  公开号：US20110014141A1

  公开（公告）日：2011-01-20

  The objective of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-α-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

  本发明的目的是增强皮肤美白效果和黑色素生成的预防效果，并提供安全稳定的用于皮肤科的局部制剂。为此，4-羟基苯基-α-D-葡萄糖苷与辅助剂如抗坏血酸及其衍生物、天然药物及其提取物、羟基羧酸及其盐、油溶性甘草提取物、龙胆提取物、酚类衍生物及其盐、胎盘提取物、曲酸及其衍生物、葡萄糖胺及其衍生物、癸二酸及其衍生物、视黄醇及其衍生物、吡哆醇及其衍生物、生育酚及其衍生物、壳聚糖及其分解产物、咖啡酸衍生物、羟基肉桂酸及其衍生物、伞形科植物提取物、菌丝培养物及其提取物、植物叶片及其提取物相结合。
• AROMATIC POLYESTER
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0077834A1

  公开（公告）日：1983-05-04

  An aromatic polyester obtained by copolycondensation of isophtalic acid and terepthalic acid or the derivatives thereof, bis(hydroxyphenyl)sulfone, and 2,2-bis(4'-hydroxyphenyl)propane. This aromatic polyester has a good moldability and provides colorless, transparent moldings by a molding process such as compression moldin, extrusion molding or injection molding. The resulting moldings possess good mechanical and electrical properties, and improved heat resistance.

  一种芳香族聚酯，由异酞酸和对苯二甲酸或其衍生物、双（羟基苯基）砜和 2,2-双（4'-羟基苯基）丙烷共聚而成。 这种芳香族聚酯具有良好的成型性，可通过压缩成型、挤压成型或注塑成型等成型工艺制成无色透明的成型品。 所制成的成型品具有良好的机械和电气性能，耐热性能也有所提高。
• Liquid substituted 2H-benzotriazole mixtures
  申请人：CIBA-GEIGY AG

  公开号：EP0337942A1

  公开（公告）日：1989-10-18

  Liquid substituted 2H-benzotriazole mixtures are prepared by alkylation with concomitant dealkylation, fragmentation and/or realkylation of 2-(2-hydroxy-5-alkylphenyl)-2H-benzotriazoles or of 2-(2-hydroxy-3,5-dialkylphenyl)-2H-benzotriazoles with straight or branched alkenes of 8 to 40 carbon atoms in the presence of an acid catalyst at 100 - 200°C. The liquid mixtures exhibit outstanding efficacy in protecting organic substrates from light induced deterioration as well as good resistance to loss by volatilization or exudation during the processing of stabilized compositions at elevated temperatures.

  液态取代的 2H 苯并三唑混合物是在 100 - 200°C 下，在酸催化剂存在下，通过 2-(2-羟基-5-烷基苯基)-2H-苯并三唑或 2-(2-羟基-3,5-二烷基苯基)-2H-苯并三唑与 8 - 40 个碳原子的直链或支链烯烃进行烷基化并同时进行脱烷基化、破碎和/或再烷基化而制备的。这种液态混合物在保护有机基质免受光引起的劣化方面表现出卓越的功效，并且在高温下加工稳定组合物时，具有良好的抗挥发或抗渗出性。
• Topical agent for dermatological use containing 4-hydroxyphenyl-alpha-D-glucopyranoside
  申请人：PENTAPHARM Ltd.

  公开号：EP1859835A2

  公开（公告）日：2007-11-28

  The objective of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe topical agents for dermatological use. For that purpose a topical composition comprising 4-hydroxyphenyl-alpha-D-glucopyranoside and UV absorber is manufactured.

  本发明的目的是增强皮肤美白效果和防止变黑效果，并提供安全的皮肤病外用制剂。为此，制造了一种由 4-羟基苯基-α-D-吡喃葡萄糖苷和紫外线吸收剂组成的外用组合物。