bis[N,N-di-(N'-methylacetamido)-L-alaninato]copper(II) | 778573-18-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bis[N,N-di-(N'-methylacetamido)-L-alaninato]copper(II)
• CAS: 778573-18-5；887116-07-6
• 化学式: C₁₈H₃₂CuN₆O₈
• 分子量: 524.033
• InChiKey: IFOOWPVYFXOBOZ-GOPSZHOCSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 乙酰胺 、 trans-bis(amino acidato)copper(II) complex of L-alanine 以 not given 为溶剂， 生成 bis[N,N-di-(N'-methylacetamido)-L-alaninato]copper(II) 、 bis[N-(N'-methylacetamido)-L-alaninato]copper(II)
  参考文献：
  名称：

  Mono- and di-N-acetamidomethylated derivatives of bis(l-alaninato)copper(II): Characterization and nucleolytic property

  摘要：

  The Mannich aminomethylation of bis(L-alaninato)copper(II), Cu(L-ala)(2), with formaldehyde and acetamide yields the bis[N-(N'-methylacetamido)-L-alaninato]copper(II) (1) and bis[N,N-di-(N'-methylacetamido)-L-alaninato]copper(II) (2) complexes. The crystal structure of 2 shows the amide N-H of the uncoordinated N-methylacetamido substituents and that of the coordinated N-methylacetamido substituents forming intra- and inter-molecular hydrogen bonding. Both complexes have been characterized by elemental analysis, UV-Vis spectroscopy, magnetic susceptibility measurements and EI mass spectroscopy. A gel electrophoresis experiment on the Soluble complex 1 in Tris-NaCl buffer at pH 8.3, from which 2 is formed, shows oxidative cleavage of DNA by I in the presence of hydrogen peroxide. The cleavage efficiency of 1 is greater than that of its precursor, Cu(L-ala)(2). (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2005.08.052