10-chloro-11b-(2-chloro-phenyl)-7-methyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one | 24111-46-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 10-chloro-11b-(2-chloro-phenyl)-7-methyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one
• 英文别名: 10-chloro-11b-(2-chlorophenyl)-7-methyl-3,5-dihydro-2H-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
• CAS: 24111-46-4
• 化学式: C₁₈H₁₆Cl₂N₂O₂
• 分子量: 363.243
• InChiKey: IAZUQIMPFWVZCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (+/-)-5,2'-Dichlor-2--benzophenon 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 10-chloro-11b-(2-chloro-phenyl)-7-methyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one
  参考文献：
  名称：

  抗焦虑镇静剂。1.苯并[6,7] -1,4-二氮杂[5,4-b]恶唑衍生物及其类似物的合成及药理作用。

  摘要：

  DOI：

  10.1021/jm00288a015

文献信息

• Multi-API Loading Prodrugs
  申请人：Zeidan Tarek A.

  公开号：US20120202823A1

  公开（公告）日：2012-08-09

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.