butyl 2-hydroxysuccinate | 197014-63-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: butyl 2-hydroxysuccinate
• 英文别名: 4-Butoxy-3-hydroxy-4-oxobutanoic acid
• CAS: 197014-63-4
• 化学式: C₈H₁₄O₅
• 分子量: 190.196
• InChiKey: LIEWIHQESDHHTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  butyl 2-hydroxysuccinate 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 、 silver(l) oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 生成
  参考文献：
  名称：

  Use of enantio-, chemo- and regioselectivity of acylase I. Resolution of polycarboxylic acid esters

  摘要：

  Acylase I was used to catalyze the enantioselective butanolysis of trimethyl 2-[(carboxymethyl)oxy]succinate (E=30) and N-carboxymethylaspartate (E=9) exclusively at the most sterically hindered of the three ester group's (the position alpha to the asymmetric centre). Gram-scale resolution allowed the preparation of the less reactive trimethyl (S)-2-[(carboxymethyl)oxy]succinate (96% e.e.), that of the (R)-butyldimethyl regioisomer (78% e.e.) at 55% conversion and finally the preparation of the corresponding trisodium carboxylate by saponification. Acylase I was shown to transform (+/-)-methyl N-acetylmethionine and (+/-)-valine to the corresponding (S)-amino acids through ester hydrolysis-N-acetyl transfer sequence with absolute chemo- and enantioselectivity. Butanolysis of methyl N-acetylmethionine stopped in the formation of the butyl ester (E=12), the valine derivative being totally unreactive. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00362-7
• 作为产物：
  描述：

  (2,5-Dioxooxolan-3-yl) 2,2,2-trifluoroacetate 、 正丁醇 生成 butyl 2-hydroxysuccinate
  参考文献：
  名称：

  Use of enantio-, chemo- and regioselectivity of acylase I. Resolution of polycarboxylic acid esters

  摘要：

  Acylase I was used to catalyze the enantioselective butanolysis of trimethyl 2-[(carboxymethyl)oxy]succinate (E=30) and N-carboxymethylaspartate (E=9) exclusively at the most sterically hindered of the three ester group's (the position alpha to the asymmetric centre). Gram-scale resolution allowed the preparation of the less reactive trimethyl (S)-2-[(carboxymethyl)oxy]succinate (96% e.e.), that of the (R)-butyldimethyl regioisomer (78% e.e.) at 55% conversion and finally the preparation of the corresponding trisodium carboxylate by saponification. Acylase I was shown to transform (+/-)-methyl N-acetylmethionine and (+/-)-valine to the corresponding (S)-amino acids through ester hydrolysis-N-acetyl transfer sequence with absolute chemo- and enantioselectivity. Butanolysis of methyl N-acetylmethionine stopped in the formation of the butyl ester (E=12), the valine derivative being totally unreactive. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00362-7

文献信息

• HARD-MASK FORMING COMPOSITION, METHOD FOR MANUFACTURING ELECTRONIC COMPONENT, AND COMPOUND AND RESIN
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20210155825A1

  公开（公告）日：2021-05-27

  A hard-mask forming composition that forms a hard mask that is used in lithography, the hard-mask forming composition including at least one of a compound represented by General Formula (sc-1) and a resin having a partial structure represented by General Formula (sc-p1). In the general formula, R 11 and R 12 are organic groups having 1 to 40 carbon atoms or hydrogen atoms; R 13 and R 14 are aromatic hydrocarbon groups having 6 to 30 carbon atoms which may have a substituent; R 13 and R 14 may be bonded to each other to form a structure having an aromatic heterocyclic ring, and the hydrogen atom of the phenylene group in the formula may be substituted with a substituent

  一种硬掩膜形成组合物，用于光刻中形成硬掩膜，该硬掩膜形成组合物包括由通用公式（sc-1）表示的化合物中的至少一种和具有由通用公式（sc-p1）表示的部分结构的树脂。在通用公式中，R11和R12是具有1至40个碳原子或氢原子的有机基团；R13和R14是具有6至30个碳原子的芳香烃基团，可能具有取代基；R13和R14可以相互连接以形成具有芳香杂环环的结构，并且在公式中苯基的氢原子可以被取代基取代。
• Waterproof material and method for applying it
  申请人：MITSUI TOATSU CHEMICALS, INC.

  公开号：EP0803531A2

  公开（公告）日：1997-10-29

  A waterproof material is disclosed herein which is obtainable by laminating many sheets of a photo-setting type fiber reinforced thermosetting resin composition comprising a resin composition containing a thermosetting resin, a photopolymerization initiator and a thickener, and a fiber reinforced material, or by laminating plural sheets of a synthetic polymer, and a waterproof application method using the waterproof material is also disclosed herein. According to the present invention, the waterproof layer can be formed on the surface of a civil engineering works or a building in a short time of about 30 minutes by a few steps without polluting a working environment. Furthermore, the waterproof layer, needless to say, has water resistance, weathering resistance, anticorrosion and substrate adhesion. In addition, it is further excellent in follow-up properties to cracks of the substrate, and walking on the waterproof layer is possible.

  本发明公开了一种防水材料，该材料可通过层压多片光固化型纤维增强热固性树脂组合物而获得，该树脂组合物包括含有热固性树脂、光聚合引发剂和增稠剂的树脂组合物以及纤维增强材料，或通过层压多片合成聚合物而获得，本发明还公开了一种使用该防水材料的防水应用方法。根据本发明，防水层可在 30 分钟左右的短时间内通过几个步骤在土木工程或建筑物表面形成，且不会污染工作环境。此外，不用说，防水层还具有耐水性、耐候性、防腐性和基底附着力。此外，它对基材裂缝的后续性能也非常出色，可以在防水层上行走。
• Method for reinforcing structures
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0861862A2

  公开（公告）日：1998-09-02

  The present invention relates to a method for reinforcing a structure comprising the steps of forming a primer layer on the surface of a structure to be reinforced; forming if necessary a putty layer on the primer layer; applying an impregnating resin on the formed primer layer provided that the putty layer in case where the putty layer is formed on the primer layer, before, after or before and after cladding with the fiber sheets, to allow the resin to penetrate into the spaces in the fiber sheets; and curing the resin,    the said primer, putty and impregnating resin comprising a resin composition which can cure at a temperature not more than 5°C.

  本发明涉及一种加固结构的方法，包括以下步骤：在待加固结构的表面形成底漆层；必要时在底漆层上形成腻子层；在底漆层上形成腻子层的情况下，在腻子层形成之前、之后或用纤维板包覆前后，在底漆层上涂抹浸渍树脂，以使树脂渗透到纤维板的空隙中；以及固化树脂、 上述底漆、腻子和浸渍树脂包括一种可在不超过 5°C 的温度下固化的树脂组合物。
• Heat-resistant hose
  申请人：TOKAI RUBBER INDUSTRIES, LTD.

  公开号：EP1568484A1

  公开（公告）日：2005-08-31

  A heat-resistant hose capable of exhibiting excellent interlaminar adhesion in a high-temperature environment. The heat-resistant hose has a laminar structure of an inner layer formed by fluorine-containing rubber (a fluorine-containing rubber layer 1) and an acrylic rubber layer 2 formed on an outer peripheral surface of the fluorine-containing rubber layer 1, wherein the acrylic rubber layer 2 is formed by a rubber composition comprising the following (A) to (D): (A) an acrylic elastomer; (B) a peroxide crosslinking agent; (C) phenothiazine; and (D) an acid receiver.

  一种耐热软管，能够在高温环境下表现出优异的层间粘合力。该耐热软管具有由含氟橡胶形成的内层（含氟橡胶层 1）和形成于含氟橡胶层 1 外周表面的丙烯酸橡胶层 2 组成的层状结构，其中丙烯酸橡胶层 2 由包含以下（A）至（D）的橡胶组合物形成： (A) 丙烯酸弹性体； (B) 过氧化物交联剂 (C) 吩噻嗪；以及 (D) 酸接收器。
• ACRYLIC RUBBER COMPOSITION AND VULCANIZATES THEREOF
  申请人：Denki Kagaku Kogyo Kabushiki Kaisha

  公开号：EP2159263A1

  公开（公告）日：2010-03-03

  To provide an acrylic rubber composition and its vulcanized product, having excellent workability and an excellent balance of the vulcanization properties, the reduction of scorching, the rubber mechanical properties, the compression set and the heat resistance. An acrylic rubber composition comprising a carboxy group-containing acrylic rubber, a novolac phenol resin salt of a diazabicycloalkene compound and a polyamine compound. Particularly, the diazabicycloalkene compound is preferably 2,3,4,6,7,8,9,10-octahydropyrimido(1,2-a)azepine or 2,3,4,6,7,8-hexahydropyrrolo(1,2-a)pyrimidine, and the polyamine compound is preferably an aromatic polyamine or an aliphatic polyamine.

  提供一种丙烯酸橡胶组合物及其硫化产品，该组合物具有极佳的加工性，并在硫化性能、减少焦烧、橡胶机械性能、压缩永久变形和耐热性方面实现了极佳的平衡。 一种丙烯酸橡胶组合物，由含羧基的丙烯酸橡胶、重氮双环烯化合物的酚醛树脂盐和多胺化合物组成。特别是，重氮双环烯化合物最好是 2,3,4,6,7,8,9,10-八氢嘧啶并(1,2-a)氮杂卓或 2,3,4,6,7,8-六氢吡咯并(1,2-a)嘧啶，多胺化合物最好是芳香族多胺或脂肪族多胺。