4-methyl-4,5,6,7-tetrahydro-1(3)H-benzoimidazole-4-carboxylic acid ethyl ester | 58729-57-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-methyl-4,5,6,7-tetrahydro-1(3)H-benzoimidazole-4-carboxylic acid ethyl ester
• 英文别名: Ethyl 4-methyl-1,5,6,7-tetrahydrobenzimidazole-4-carboxylate
• CAS: 58729-57-0
• 化学式: C₁₁H₁₆N₂O₂
• 分子量: 208.26
• InChiKey: QFRBPEYAZZPHGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
  申请人：SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.

  公开号：US11168088B2

  公开（公告）日：2021-11-09

  The present disclosure relates to pyridinamine-substituted heterotricyclo compounds, a preparation method thereof, and a use thereof in medicines. Specifically, a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, a preparation method and a use thereof are disclosed, wherein the groups in the formula (I) are as defined in the Description and claims.

  本公开涉及吡啶胺取代的杂环化合物、其制备方法及其在药物中的用途。具体地说，本发明公开了一种式（I）化合物或其药学上可接受的盐、立体异构体、溶液剂或原药，以及其制备方法和用途，其中式（I）中的基团如说明书和权利要求书中所定义。
• PYRIDYLAMINO SUBSTITUTED HETEROTRICYCLIC COMPOUNDS, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
  申请人：SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.

  公开号：US20200039983A1

  公开（公告）日：2020-02-06

  The present disclosure relates to pyridinamine-substituted heterotricyclo compounds, a preparation method thereof, and a use thereof in medicines. Specifically, a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, a preparation method and a use thereof are disclosed, wherein the groups in the formula (I) are as defined in the Description and claims.