N-(4,5α-epoxy-3,14-dihydroxy-17-propyl-morphinan-6β-yl)-phthalimide | 160359-66-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: N-(4,5α-epoxy-3,14-dihydroxy-17-propyl-morphinan-6β-yl)-phthalimide
• 英文别名: 2-[(4R,4aS,7R,7aR,12bS)-4a,9-dihydroxy-3-propyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]isoindole-1,3-dione
• CAS: 160359-66-0
• 化学式: C₂₇H₂₈N₂O₅
• 分子量: 460.53
• InChiKey: QWFXQKFWFMNPQP-KQIADLJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  90.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  酒石酸 、 N-(4,5α-epoxy-3,14-dihydroxy-17-propyl-morphinan-6β-yl)-phthalimide 生成 N-(4,5α-epoxy-3,14-dihydroxy-17-propyl-morphinan-6β-yl)-phthalimide tartaric acid salt
  参考文献：
  名称：

  REMEDIES OR PREVENTIVES FOR URINARY INCONTINENCE AND MORPHINAN DERIVATIVES HAVING NITROGEN-CONTAINING HETEROCYCLIC GROUP

  摘要：

  公开号：

  EP1555266B1
• 作为产物：
  描述：

  在 盐酸羟胺 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 乙醇 、 水 、 苯 为溶剂， 反应 1.17h， 生成 N-(4,5α-epoxy-3,14-dihydroxy-17-propyl-morphinan-6β-yl)-phthalimide
  参考文献：
  名称：

  Stereoselective synthesis of β-naltrexol, β-naloxol β-naloxamine, β-naltrexamine and related compounds by the application of the mitsunobu reac

  摘要：

  As a continuation of our work, aimed at adopting the Mitsunobu reaction in the morphine series, a few representatives of dihydroisocodeines and dihydroisomorphines and their 14 beta-hydroxy analogues were prepared. p-Nitrobenzoic acid was used as carboxylic acid and the prepared esters were cleaved to obtain the title compounds. Using phthalimide as acidic component several new 6 beta-phthalimidodihydromorphine and dihydrocodeine derivatives and their 14 beta-hydroxy analogues have been synthesized. Cleavage of the phthalimido derivatives with hydrazine hydrate afforded the corresponding 6 beta-amino derivatives.

  DOI：

  10.1016/s0040-4020(01)85541-1

文献信息

• US7320984B2
  申请人：——

  公开号：US7320984B2

  公开（公告）日：2008-01-22