Methyl 2-[acetyloxy(pyridin-3-yl)methyl]prop-2-enoate | 884537-06-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 2-[acetyloxy(pyridin-3-yl)methyl]prop-2-enoate
• CAS: 884537-06-8
• 化学式: C₁₂H₁₃NO₄
• 分子量: 235.24
• InChiKey: BXFHAYPHXPFQAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 2-[acetyloxy(pyridin-3-yl)methyl]prop-2-enoate 在 三乙烯二胺 、 盐酸 、 sodium hydroxide 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 3.17h， 生成 6-methyl-3-methylene-4-pyridin-3-yltetrahydropyran-2-one
  参考文献：
  名称：

  Persistent splenomegaly in an adult female with homozygous sickle cell anemia

  摘要：

  Sickle cell anemia (SCA) is associated with repeated episodes of erythrostasis in the spleen, which lead to thrombosis and infarction of the spleen resulting in "autosplenectomy" which is usually complete by 8 years of age.We present a case of a 22-year-old female who presented with complaints of fever, bone pain and joint swelling. On examination she had pallor, icterus and moderate splenomegaly. Her hemoglobin was 7.5g/dl. Peripheral smear showed many sickled red cells. Slide test for sickling was positive with 2% sodium metabisulphite. Hemoglobin electrophoresis revealed a single band in the hemoglobin S, D, and G region. No band was seen in the HbA & HbA(2) region. HbF level was 0%. USG showed an enlarged spleen with few defined hypoechoeic lesion.We present this case because of rarity of association of homozygous SCA with splenomegaly in this age group, the confusion that echogenic lesions in spleen can create and to emphasize the risk of sequestration crises, which remains in such cases.

  DOI：

  10.1080/01650420500328365
• 作为产物：
  描述：

  3-吡啶甲醛 在 三乙烯二胺 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 49.0h， 生成 Methyl 2-[acetyloxy(pyridin-3-yl)methyl]prop-2-enoate
  参考文献：
  名称：

  N-溴代琥珀酰亚胺介导的3-芳基烯丙基叠氮化物的自由基环化：3-取代的喹啉的合成

  摘要：

  N-溴代琥珀酰亚胺的可见光照射是一种有效的手段，可通过α-氢提取并随后挤出二氮，将2-（叠氮基甲基）-3-芳基丙烯酸甲酯和2-（叠氮基甲基）-3-芳基丙烯腈转化为相应的亚氨基。如此形成的亚氨基自由基随后在芳基环上进行分子内邻位攻击，分别得到喹啉-3-羧酸甲酯和喹啉-3-腈。

  DOI：

  10.1002/adsc.201400637