4-[5-[(2R)-2-[5-(3-chlorophenyl)-1,2-oxazol-3-yl]pyrrolidin-1-yl]-4-methyl-1,2,4-triazo1-3-yl]-N-methyl-benzamide | 1147111-55-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[5-[(2R)-2-[5-(3-chlorophenyl)-1,2-oxazol-3-yl]pyrrolidin-1-yl]-4-methyl-1,2,4-triazo1-3-yl]-N-methyl-benzamide
• 英文别名: 4-[5-[(2R)-2-[5-(3-chlorophenyl)-1,2-oxazol-3-yl]pyrrolidin-1-yl]-4-methyl-1,2,4-triazol-3-yl]-N-methylbenzamide
• CAS: 1147111-55-4
• 化学式: C₂₄H₂₃ClN₆O₂
• 分子量: 462.939
• InChiKey: LFHNWOYXXQEQDS-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  89.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 1,2,4-TRIAZOLE CARBOXYLIC ACID DERIVATIVES AS MODULATORS OF MGLUR5
  申请人：GRANBERG Kenneth

  公开号：US20090111811A1

  公开（公告）日：2009-04-30

  The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.

  本发明涉及新型化合物，其制备方法以及这些新型化合物在治疗中的应用和包含这些新型化合物的药物组合物。
• METABOTROPIC GLUTAMATE RECEPTOR GROUP I ANTAGONISTS FOR TREATMENT OF ABNORMAL UNION OF TISSUE
  申请人：Pharmalundensis AB

  公开号：EP2672971A1

  公开（公告）日：2013-12-18
• [EN] 1,2,4-TRIAZOLE CARBOXYLIC ACID DERIVATIVES AS MODULATORS OF MGLUR5<br/>[FR] DÉRIVÉS D'ACIDE 1,2,4-TRIAZOLE CARBOXYLIQUE UTILISÉS EN TANT QUE MODULATEURS DE MGLUR5
  申请人：ASTRAZENECA AB

  公开号：WO2009054787A1

  公开（公告）日：2009-04-30

  1,2,4-triazole carboxylic acid derivatives and their use as modulators of mGluR5 (F).
• [EN] METABOTROPIC GLUTAMATE RECEPTOR GROUP I ANTAGONISTS FOR TREATMENT OF ABNORMAL UNION OF TISSUE<br/>[FR] ANTAGONISTES DE GROUPE I DU RÉCEPTEUR MÉTABOTROPIQUE DU GLUTAMATE POUR LE TRAITEMENT D'UNE UNION ANORMALE DE TISSUS
  申请人：REDECO CHEM AB

  公开号：WO2012108831A1

  公开（公告）日：2012-08-16

  Use of a metabotropic glutamate receptor group I antagonist, or a pharmaceutically acceptable salt, prodrug or an optical isomer thereof, for the manufacture of a medicament for the treatment or the prevention of abnormal union of tissue, is provided. A related method is also provided.