benzhydryl (2S,3R,5R,6R)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-formyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | 229490-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzhydryl (2S,3R,5R,6R)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-formyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• CAS: 229490-01-1
• 化学式: C₂₈H₃₅NO₇SSi
• 分子量: 557.74
• InChiKey: REAOZVAWFBLXQK-JVBXDARBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.88
• 重原子数：
  38.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  107.05
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  benzhydryl (2S,3R,5R,6R)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-formyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 在 N-甲基吡咯烷酮 、 氟化铵 、 氢氟酸 、 碳酸氢钠 、 间甲酚 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Sodium; (2S,3S,5R,6R)-3-((E)-2-cyano-vinyl)-6-hydroxymethyl-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate
  参考文献：
  名称：

  6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C β-lactamases II

  摘要：

  Two stereoselective processes for the synthesis of novel 3,6-disubstituted penam sulfone derivatives were developed. One 6 beta-(l-hydroxyethyl) and four 6 beta-hydroxymethyl penam sulfone derivatives were synthesized. All four 6 beta-(hydroxymethyl)penam sulfone derivatives demonstrated good IC50 against both TEM-1 and AmpC beta-lactamases. of these, 6 beta-hydroxymethyl penam sulfone derivative 25 was the most active inhibitor which was able to restore the activity of piperacillin in vitro and in vivo against both TEM-1 and AmpC beta-lactamases producing organisms. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00107-9
• 作为产物：
  描述：

  (2S,3R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxymethyl-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 在 pyridinium chlorochromate 作用下， 以64%的产率得到benzhydryl (2S,3R,5R,6R)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-3-formyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  参考文献：
  名称：

  6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C β-lactamases II

  摘要：

  Two stereoselective processes for the synthesis of novel 3,6-disubstituted penam sulfone derivatives were developed. One 6 beta-(l-hydroxyethyl) and four 6 beta-hydroxymethyl penam sulfone derivatives were synthesized. All four 6 beta-(hydroxymethyl)penam sulfone derivatives demonstrated good IC50 against both TEM-1 and AmpC beta-lactamases. of these, 6 beta-hydroxymethyl penam sulfone derivative 25 was the most active inhibitor which was able to restore the activity of piperacillin in vitro and in vivo against both TEM-1 and AmpC beta-lactamases producing organisms. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00107-9