ethyl 2-(ethoxymethyl)-3-[(1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl)methyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate | 1221682-50-3

• 分子结构分类: 有机化合物
• 英文名称: ethyl 2-(ethoxymethyl)-3-[(1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl)methyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate
• 英文别名: ethyl 5-(ethoxymethyl)-3-oxo-4-[[1-[(2R,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]triazol-4-yl]methyl]-8-thia-4,6,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5-triene-11-carboxylate
• CAS: 1221682-50-3
• 化学式: C₃₂H₄₀N₆O₁₃S
• 分子量: 748.768
• InChiKey: UVKKSYPSBONALH-JJYMYUOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  52
• 可旋转键数：
  17
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  245
• 氢给体数：
  0
• 氢受体数：
  17

反应信息

• 作为产物：
  描述：

  ethyl 2-(ethoxymethyl)-4-oxo-3-(2-propynyl)-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate 、 1-azido-1-deoxy-β-D-glucopyranoside tetraacetate 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 四氢呋喃 、 水 为溶剂， 以91%的产率得到ethyl 2-(ethoxymethyl)-3-[(1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl)methyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate
  参考文献：
  名称：

  A convenient method for constructing novel tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]-pyrimidinones-carbohydrate and amino acid conjugates via copper(I)-catalyzed alkyne-azide ‘Click Chemistry’

  摘要：

  Novel conjugates of tetrahydropyridothienopyrimidones and carbohydrates of amino acids linked by 1,2,3-triazoles were synthesized After establishing the tetrahydropyridothienopyrimidones ring system by ring closure, propargyl groups were introduced by N-alkylation Cu-catalyzed cycloaddition of the propargyl products with azido group containing hexoses or amino acids gives the corresponding 1,2,3-triazoles in high yields This methodology also allowed attaching two carbohydrate molecules to the tetrahydropyridothienopyrimidone core Interesting dependence of the regioselectivity of the N-propargylation of the pyrimidone ring oil the exocyclic substituent found adjacent to the pyrimidine-N-atom was observed A remarkable case of a non-catalyzed intramolecular [3+2]-cycloaddition of an alkyne with ail azide to a 1,2,3-triazole was observed. which occurred in the solid state at it or below (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.01.071