bis-MPA-OH dendrimer, trimethylol propane core, generation 3 | 1033556-21-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: bis-MPA-OH dendrimer, trimethylol propane core, generation 3
• 英文别名: [3-[3-[2,2-bis[[3-[3-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxy-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxy-2-[[3-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxy-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxymethyl]butoxy]-2-[[3-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxy-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methylpropanoyl]oxymethyl]-2-methyl-3-oxopropoxy]-2-[[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoyl]oxymethyl]-2-methyl-3-oxopropyl] 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• CAS: 1033556-21-6
• 化学式: C₁₁₁H₁₈₂O₆₆
• 分子量: 2572.63
• InChiKey: AGYRSRVUVSKOQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -10.6
• 重原子数：
  177
• 可旋转键数：
  109
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  1040
• 氢给体数：
  24
• 氢受体数：
  66

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以100%的产率得到bis-MPA-OH dendrimer, trimethylol propane core, generation 3
  参考文献：
  名称：

  咪唑化物活化的化合物促进氟化物的酯化：树状聚合物的模块化和可持续方法

  摘要：

  基于对在结构上完美的聚合物的简便，可持续的合成方法不断增长的需求，我们在此描述了利用1,1'-羰基二咪唑（CDI）进行酯化反应的显着改进。氟化铯被证明是完成这些反应的必要催化剂。该方法已成功应用于采用传统和加速生长策略的结构无缺陷且功能强大的聚酯树枝状聚合物的合成。在不到一天的总反应时间内，分离出了分子量为22.080 Da和192个外围羟基的第六代bis-MPA树状聚合物。使用简单的纯化步骤，在可持续的条件下，可以高产率（> 90％）获得大量的树枝状大分子。

  DOI：

  10.1002/anie.201411370

文献信息

• Hyperbranched Polyester Hydrogels with Controlled Drug Release and Cell Adhesion Properties
  作者：Hongbin Zhang、Alpesh Patel、Akhilesh K. Gaharwar、Silvia M. Mihaila、Giorgio Iviglia、Shilpaa Mukundan、Hojae Bae、Huai Yang、Ali Khademhosseini

  DOI：10.1021/bm301825q

  日期：2013.5.13

  Hyperbranched polyesters (HPE) have a high efficiency to encapsulate bioactive agents, including drugs, genes, and proteins, due to their globe-like nanostructure. However, the use of these highly branched polymeric systems for tissue engineering applications has not been broadly investigated. Here, we report synthesis and characterization of photocrosslinkable HPE hydrogels with sustained drug release characteristics for cellular therapies. These HPE can encapsulate hydrophobic drug molecules within the HPE cavities due to the presence of a hydrophobic inner structure that is otherwise difficult to achieve in conventional hydrogels. The functionalization of HPE with photocrosslinkable acrylate moieties renders the formation of hydrogels with a highly porous interconnected structure and mechanically tough network. The compressive modulus of HPE hydrogels was tunable by changing the crosslinking density. The feasibility of using these HPE networks for cellular therapies was investigated by evaluating cell adhesion, spreading, and proliferation on hydrogel surface. Highly crosslinked and mechanically stiff HPE hydrogels have higher cell adhesion, spreading, and proliferation compared to soft and complaint HPE hydrogels. Overall, we showed that hydrogels made from HPE could be used for biomedical applications that require spatial control of cell adhesion and controlled release of hydrophobic clues.