| 1024021-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1024021-56-4
• 化学式: C₁₆H₂₁NO₃
• 分子量: 275.348
• InChiKey: ZBOUKTQJEAIVHK-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  丙酮酸甲酯 、 在 三氟化硼乙醚 作用下， 以 乙腈 为溶剂， 生成 2-methyl-c-5-[3-(5-methyl-2-phenyloxazol-4-yl)propyl]-1,3-dioxane-r-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

  摘要：

  A new series of 1,3-dioxane-2-carboxylic acid derivatives was synthesized and evaluated for agonist activity at human peroxisome proliferator-activated receptor ( PPAR) subtypes. Structure-activity relationship studies led to the identification of 2-methyl-c-5-[4-(5-methyl-2-phenyl-1,3-oxazol-4-yl) butyl]-1,3-dioxane-r-2-carboxylic acid 4b as a potent PPAR alpha agonist with high subtype selectivity at human receptor subtypes. This compound exhibited a substantial hypolipidemic effect in type 2 diabetic KK-A(y) mice. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.086
• 作为产物：
  描述：

  C₂₀H₂₅NO₅ 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成
  参考文献：
  名称：

  Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists

  摘要：

  A new series of 1,3-dioxane-2-carboxylic acid derivatives was synthesized and evaluated for agonist activity at human peroxisome proliferator-activated receptor ( PPAR) subtypes. Structure-activity relationship studies led to the identification of 2-methyl-c-5-[4-(5-methyl-2-phenyl-1,3-oxazol-4-yl) butyl]-1,3-dioxane-r-2-carboxylic acid 4b as a potent PPAR alpha agonist with high subtype selectivity at human receptor subtypes. This compound exhibited a substantial hypolipidemic effect in type 2 diabetic KK-A(y) mice. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.086