维达列汀杂质44 | 52208-82-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 维达列汀杂质44
• 英文名称: glycyl proline
• 英文别名: GP-NH2；Glycyl-L-prolinamide；(2S)-1-(2-aminoacetyl)pyrrolidine-2-carboxamide
• CAS: 52208-82-9
• 化学式: C₇H₁₃N₃O₂
• 分子量: 171.199
• InChiKey: LENAFVMQJFJAGN-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  89.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  维达列汀杂质44 生成 (8As)-六氢吡咯并[1,2-a]吡嗪-1,4-二酮
  参考文献：
  名称：

  Lenman, Morag M.; Ingham, Scott L.; Gani, David, Journal of the Chemical Society. Chemical communications, 1996, # 1, p. 85 - 88

  摘要：

  DOI：
• 作为产物：
  描述：

  (9aS)-六氢-1H-吡咯并[2,1-d][1,2,5]三氮杂卓-1,5(2H)-二酮 在 氨 、 sodium 作用下， 生成 维达列汀杂质44
  参考文献：
  名称：

  Lenman, Morag M.; Ingham, Scott L.; Gani, David, Journal of the Chemical Society. Chemical communications, 1996, # 1, p. 85 - 88

  摘要：

  DOI：

文献信息

• 嘌呤类化合物、中间体、制备方法及其应用
  申请人：上海医药工业研究院

  公开号：CN103373999B

  公开（公告）日：2016-01-13

  本发明公开了一种黄嘌呤类化合物I，R1为2-氰基苯基或氢；R2为2-氰基苄基；R3为、氨基或，其中，n＝2～4，m＝2～3，D为H或NH2，E为CH2或NH。一种黄嘌呤类化合物I的制备方法：将化合物II与R3H进行亲核取代反应；或者①将化合物II与R-3-叔丁氧酰基氨基哌啶进行亲核取代反应，②脱叔丁氧酰基保护基。本发明还公开了黄嘌呤类化合物I的任一中间体，R1和R2如上所述。黄嘌呤类化合物I在制备DPP-4酶活性抑制剂，或通过抑制DPP-4酶来治疗和/或预防与其相关的疾病的药物中的应用。本发明的黄嘌呤类化合物为DPP-4抑制剂研发提供了一个新方向，对开发潜在DPP-4抑制剂具有重要意义。
• Amides of antibiotic ge 2270 factors
  申请人：GRUPPO LEPETIT S.p.A.

  公开号：EP0494078A1

  公开（公告）日：1992-07-08

  The present invention is directed to novel amide derivatives of antibiotic GK 2270 compounds and a process for preparing them. Said amide derivatives are antimicrobial agents active against gram positive bacteria as well as gram negative bacteria.

  本发明涉及抗生素 GK 2270 化合物的新型酰胺衍生物及其制备方法。所述酰胺衍生物是对革兰氏阳性菌和革兰氏阴性菌均有活性的抗菌剂。
• Advancing In-Depth N-Terminomics Detection with a Cleavable 2-Pyridinecarboxyaldehyde Probe
  作者：Xiaohan Song、Xuelian Ren、Qi Mei、Hong Liu、He Huang

  DOI：10.1021/jacs.4c02222

  日期：2024.3.13

  development. Herein, we have developed a cleavable 2-pyridinecarboxyaldehyde probe (2PCA-Probe) that enables efficient and in-depth N-terminomics detection, addressing limitations of previous methods. Furthermore, we unexpectedly discovered a new marker capable of identifying N-terminal chemical labeling with the 2PCA-Probe and elucidated the reaction mechanism. Using this probe, we identified 4686 N-terminal

  蛋白水解是蛋白酶催化的不可逆翻译后修饰，在各种生物过程中发挥着至关重要的作用。探索病理组织中异常水解的蛋白质是阐明疾病发展机制的重要方法。在此，我们开发了一种可裂解的 2-吡啶甲醛探针 (2PCA-Probe)，可实现高效、深入的 N 末端组学检测，解决了先前方法的局限性。此外，我们意外地发现了一种能够用2PCA-Probe识别N端化学标记的新标记，并阐明了反应机制。使用该探针，我们在结直肠癌和癌旁组织中鉴定了 4686 个 N 端肽，显着扩展了 N 端组的深度，揭示了异常蛋白水解在结直肠癌发展中的潜在作用。
• Foot and mouth disease leader protease (Lbpro): Investigation of prime side specificity allows the synthesis of a potent inhibitor
  作者：Jorge Alexandre Nogueira Santos、Diego M. Assis、Iuri Estrada Gouvea、Wagner A.S. Júdice、Mario Augusto Izidoro、Maria Aparecida Juliano、Tim Skern、Luiz Juliano

  DOI：10.1016/j.biochi.2011.10.016

  日期：2012.3

  Foot and mouth disease virus expresses its genetic information as a single polyprotein that is translated from the single-stranded RNA genome. Proteinases contained within the polyprotein then generate the mature viral proteins. The leader protease (Lb(pro)) performs the initial cleavage by freeing itself from the growing polypeptide chain; subsequently, Lb(pro) cleaves the two homologues of the host cell protein eukaryotic initiation factor 4G (eIF4G). We showed that Lb(pro) possesses specific binding sites at the non prime side from S-1 down to S-7 [Santos et al. (2009) Biochemistry, 48, 7948-7958]. Here, we demonstrate that Lb(pro) has high prime side specificity at least down to the S-5' site. Lb(pro) is thus not only one of the smallest papain-like cysteine peptidases but also one of the most specific. It can still however cleave between both K down arrow G and G down arrow R pairs. We further determined the two-step irreversible inhibition (E + I <-> EI -> E - I) kinetic parameters of two known irreversible epoxide-based inhibitors of cysteine proteinases, E64 and CA074 on Lb(pro) that show for the reversible step (E + I <-> EI) K-i = 3.4 mu M and 11.6 mu M, and for the irreversible step (EI -> E-I) k(4) = 0.16 and 0.06 min(-1), respectively. Knowledge of the Lb(pro) specificity led us to extend E64 by addition of the dipeptide R-P. This compound, termed E64-R-P-NH2, irreversibly inhibited Lb(pro) with a K-i = 30 nM and k(4) = 0.01 min(-1) and can serve as the basis for design of specific inhibitors of FMDV replication. (C) 2011 Elsevier Masson SAS. All rights reserved.
• LUNKENHEIMER, WINFRIED;BRANDES, WILHELM;HANSS. LER, GERD
  作者：LUNKENHEIMER, WINFRIED、BRANDES, WILHELM、HANSS. LER, GERD

  DOI：——

  日期：——