| 1057642-51-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• CAS: 1057642-51-9
• 化学式: C₂₇H₄₃N₃O₆*ClH
• 分子量: 542.116
• InChiKey: WNIGTSMAVGPAKR-VBJHUAPBSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (3R,6R,9S,13S)-9-benzyl-3-[(2S)-butan-2-yl]-13-[(2S)-hexan-2-yl]-6-methyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone
  参考文献：
  名称：

  Synthesis and biological evaluation of a focused library of beauveriolides

  摘要：

  Fungal beauveriolide III (1b), discovered as an inhibitor of lipid droplet accumulation in mouse macrophages and showing antiatherogenic activity in mouse model, consists of L-Phe, L-Ala, D-allo-Ile, and (3S, 4S)-3-hydroxy-4-methyloctanoic acid moieties. A combinatorial library of beauveriolide analogues focusing on L-Ala and D-allo-Ile of 1b was synthesized by combinatorial synthesis. Among them, D-Ala analogues consisting of A{2} improved their solubility, while those with 7{1, 3,2}, 7{2, 3,1}, and 7{2, 3,2} were 20 times more potent than 1b. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.054
• 作为产物：
  描述：

  在 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Synthesis and biological evaluation of a focused library of beauveriolides

  摘要：

  Fungal beauveriolide III (1b), discovered as an inhibitor of lipid droplet accumulation in mouse macrophages and showing antiatherogenic activity in mouse model, consists of L-Phe, L-Ala, D-allo-Ile, and (3S, 4S)-3-hydroxy-4-methyloctanoic acid moieties. A combinatorial library of beauveriolide analogues focusing on L-Ala and D-allo-Ile of 1b was synthesized by combinatorial synthesis. Among them, D-Ala analogues consisting of A{2} improved their solubility, while those with 7{1, 3,2}, 7{2, 3,1}, and 7{2, 3,2} were 20 times more potent than 1b. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.054