K[(glycylglycinato)(methioninato)Cu] | 1431303-20-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: K[(glycylglycinato)(methioninato)Cu]
• 英文别名: [Cu(GlyGly)Met]K
• CAS: 1431303-20-6
• 化学式: C₄H₆N₂O₃*C₅H₁₀NO₂S*Cu*K
• 分子量: 380.953
• InChiKey: JNWPAAQSXZNEGV-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -6.59
• 重原子数：
  20.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  163.47
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  copper(II) nitrate trihydrate 、 双甘肽 、 DL-蛋氨酸 、 potassium hydroxide 以 水 为溶剂， 反应 15.0h， 以82%的产率得到K[(glycylglycinato)(methioninato)Cu]
  参考文献：
  名称：

  Solution and solid state study of copper(II) ternary complexes with some dipeptides presence in Aβ-42 peptide and methionine

  摘要：

  The ternary complexes of Cu(II) with some dipeptides and methionine were studied both in aqueous solution and in solid state. The formation constants of copper(II) ternary complexes were calculated by potentiometric titration at 25 degrees C and mu = 0.1 mol L-1. The values of the constants for CulL(1)L(2) species (L-1 = GlyGly, GlyVal, GlyLeu or GlyPhe; L-2 = Met) were 15.66, 15.75, 15.69 and 16.31, respectively. The complexes [Cu(GlyGly)Met]K (1), [Cu(GlyVal)Met]K center dot 2H(2)O (2), [Cu(GlyLeu)(Met)(H2O)(2)]K center dot H2O (3) and [Cu(GlyPhe)(Met)(H2O)]K center dot 2H(2)O (4) were isolated in pH around 7 and characterized through microanalyses, thermogravimetry, UV-Vis, infrared and EPR spectroscopies. The presence of the sulfur noncoordinated to metal in these ternary complexes can exert reduction action in biological systems under stress conditions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2013.02.010