4-benzoxazol-2-yl-N-methyl-N-{(1R,3S)-3-[(R)-(tetrahydro-furan-3-yl)carbamoyl]-cyclopentyl}-benzamide | 1610513-83-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-benzoxazol-2-yl-N-methyl-N-{(1R,3S)-3-[(R)-(tetrahydro-furan-3-yl)carbamoyl]-cyclopentyl}-benzamide
• 英文别名: 4-(1,3-benzoxazol-2-yl)-N-methyl-N-[(1R,3S)-3-[[(3R)-oxolan-3-yl]carbamoyl]cyclopentyl]benzamide
• CAS: 1610513-83-1
• 化学式: C₂₅H₂₇N₃O₄
• 分子量: 433.507
• InChiKey: XLTHBFWBEXNGAX-XUVXKRRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES PARASITAIRES
  申请人：IRM LLC

  公开号：WO2014078813A1

  公开（公告）日：2014-05-22

  The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease, such as malaria, caused by a Plasmodium parasite.

  本发明提供了式I的化合物：[在此插入公式]或其药学上可接受的盐、互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的药物组合物以及使用这种化合物治疗、预防、抑制、改善或根除由疟原虫引起的疟疾等疾病的方法。
• [EN] 3-AMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES<br/>[FR] DÉRIVÉS DE 3-AMINOCYCLOPENTANE CARBOXAMIDE
  申请人：MERCK PATENT GMBH

  公开号：WO2014075754A1

  公开（公告）日：2014-05-22

  Compounds of the formula (I) in which R1, R4, R, X1, X2, X3, X4, q and W have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

  式（I）中R1、R4、R、X1、X2、X3、X4、q和W的含义如权利要求1所示，是脂肪酸合成酶的抑制剂，可用于治疗癌症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。
• 3-AMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES
  申请人：MERCK PATENT GMBH

  公开号：US20160264517A1

  公开（公告）日：2016-09-15

  Compounds of the formula I in which R 1 , R 4 , R, X 1 , X 2 , X 3 , X 4 , q and W have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

  式子I中，R1、R4、R、X1、X2、X3、X4、q和W的含义如权利要求书1所示，是脂肪酸合酶的抑制剂，可用于治疗癌症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
  申请人：Novartis AG

  公开号：EP2920177A1

  公开（公告）日：2015-09-23
• US9732032B2
  申请人：——

  公开号：US9732032B2

  公开（公告）日：2017-08-15