trimethyl 2,3,5-trimethylhexane-2,3,5-tricarboxylate | 17060-93-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: trimethyl 2,3,5-trimethylhexane-2,3,5-tricarboxylate
• 英文别名: 2.2.4-Trimethyl-4-<1-methyl-1-methoxycarbonyl-aethyl>-glutarsaeuredimethylester；2,3,5-Trimethyl-2,3,5-hexantricarbonsaeure-trimethylester；trimethyl 1,1,2,4-tetramethylpentane-1,2,4-tricarboxylate
• CAS: 17060-93-4
• 化学式: C₁₅H₂₆O₆
• 分子量: 302.368
• InChiKey: DIPBDOUMHOCMFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.95
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  78.9
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  异丁酸甲酯 在 二叔丁基过氧化物 作用下， 生成 trimethyl 2,3,5-trimethylhexane-2,3,5-tricarboxylate
  参考文献：
  名称：

  Reactions of ester-free radicals. The 2-carbomethoxy-2-propyl radical

  摘要：

  DOI：

  10.1021/jo01273a037

文献信息

• The Relationship Between Menarche and Depression in Adolescence
  作者：Leslie Born、Meir Steiner

  DOI：10.1017/s1092852900007896

  日期：2001.2

  Prior to adolescence, the rates of depression are similar in girls and boys, or are slightly higher in boys. However, with the onset of puberty, the gender proportion of depression dramatically shifts to a 2:1 female to male ratio. What is the relationship between menarche and the onset of major depression in early adolescence? A recent theoretical model proposes that vulnerability to depression may be rooted in normal female hormonal maturational processes and gender socialization. Information regarding the management of depression in adolescent and young adult women is provided, including gender differences in the presentation of depressive symptoms, instruments to facilitate assessment, and treatment options. Pubertal and other hormonal changes should be monitored prospectively along with individual, genetic, constitutional, and psychological characteristics. The burden of illness associated with onset of depression following menarche reinforces the importance of expeditious recognition and intervention.

  摘要 在青春期之前，女孩和男孩的抑郁症发病率相似，或者男孩略高。然而，随着青春期的到来，抑郁症的性别比例急剧转变为男女比例为 2:1。初潮与青春期早期重度抑郁症的发病之间有什么关系？最近的一个理论模型提出，易患抑郁症可能源于正常的女性荷尔蒙成熟过程和性别社会化。本文提供了有关青春期和年轻成年女性抑郁症治疗的信息，包括抑郁症状表现形式的性别差异、评估工具和治疗方案。应前瞻性地监测青春期和其他荷尔蒙变化，以及个人、遗传、体质和心理特征。月经初潮后出现的抑郁症所带来的疾病负担，更加凸显了迅速识别和干预的重要性。
• Holland, Kelvyn A.; Rae, Ian D., Australian Journal of Chemistry, 1987, vol. 40, # 4, p. 687 - 692
  作者：Holland, Kelvyn A.、Rae, Ian D.

  DOI：——

  日期：——
• BIZILJ, S.;KELLY, D. P.;SERELIS, A. K.;SOLOMON, D. H.;WHITE, K. E., AUSTRAL. J. CHEM., 1985, 38, N 11, 1657-1673
  作者：BIZILJ, S.、KELLY, D. P.、SERELIS, A. K.、SOLOMON, D. H.、WHITE, K. E.

  DOI：——

  日期：——